T & B Cell Activation

Question 1

When does signal one arrive for B cells ?

Answer 1

BCR binds to antigen

Question 2

What happens as a result of binding ?

Answer 2

B cell can interact with a t helps cell

Question 3

What did the B cells present to the T cell ?

Answer 3

Epitopes from specific antigen

Question 4

What does activated T cell express on surface ?

Answer 4

CD40L which binds to B cell surface

Question 5

What does this do?

Answer 5

Allows CD40L to bind to CD40 to transmit signal 2 to B cell

Question 6

Is the following statement true ?
BCR on B cells are capable of binding antigens in their native form

Answer 6

True

Question 7

What happens as a result of BCR binding directly ?

Answer 7

BCR can bind directly to epitope present on viral envelope or bacteria surface protein

Question 8

Can T cells recognise antigens in their native form?

Answer 8

No

Question 9

Where does T cell activation start ?

Answer 9

Antigen recognition

Question 10

How do T cells recognise antigens ?

Answer 10

Mjst be presented on MHC molecules on APC

Question 11

What 2 signals do they need ?

Answer 11

CD28 &CD3

Question 12

What does CD28 do?

Answer 12

Amplifies TCR signal

Question 13

What does CD3 do ?

Answer 13

Transduces signals into the cell leading to T cell activation