PPR Flashcards
1
Q
Where are they expressed ?
A
Throughout the body but mainly dendritic and macrophage cells
2
Q
Why are they important ?
A
Play an integral role of the innate immune system
3
Q
What do they recognise ?
A
Components of microbe such as PAMP but also self antigens DAMPS
4
Q
What are pamps
A
Pattern associated molecular patterns
5
Q
What are damps ?
A
Danger associated molecule patterns
6
Q
What are examples ?
A
Toll like receptors and C-type lectin receptors
7
Q
What does binding of PPRs result in?
A
Production of pro-inflammatory cytokines, chemokines and antiviral molecules but the degree of production of dictated by ligand that binds
