Vasodilators

Question 1

Vasodilator

-Stops second step in angiotensin activation

Answer 1

Enalapril

Question 2

Vasodilator
-Angiotensin receptor antagonist–> blocks pro-hypertension effects of angiotensin = decrease salt and water retension, decrease sympathetic effects, decrease vasoconstriction

Answer 2

Losartan

Question 3

Vasodilator

• Ca channel antagonist
• Vascular specific = don’t affect heart

Answer 3

Amlodipine

Question 4

Vasodilator

• NO donor
• Most effects on venous side–> decreased preload
  
  • Good for use during congestive heart failure
• Develop resistance with continuous use over time

Answer 4

Nitroglycerine

Question 5

Vasodilator

• NO donor
• Strong dilation of venous and arterial side–> decrease preload and afterload–> profound drop in BP–> only use in hypertensive emergencies
• Degrades on exposure to light–> produces cyanide = clear or lightbrown color is okay, other color don’t use

Answer 5

Sodium nitroprusside

Question 6

Vasodilator

• Phosphodiesterase inhibitor
• Up regulated in pulmonary hypertension

Answer 6

Sildenaphil

Question 7

Vasodilator

• Potassium channel activators
• -> hyperpolarization–> less depolarization–> decreased opening of Ca channel
• Rarely used

Answer 7

Minoxidil

Question 8

Vasodilator

• Mechanism unclear
• Potent
• Reflex tachycardia, fluid retention
• Used to treat mitral insufficiency

Answer 8

Hydralazine