GI and Liver Therapeutics Flashcards
1
Q
Antiemetic
- Block A2 adrenergic receptors - Inexpensive - Cause sedation, hypotension
A
Phenothiazine
2
Q
Antiemetic
- Dopamine antagonist blocks effects of compounds triggering chemoreceptors - -Increased upper GI motility, no effect on colonic motility - Excitability at high doses
A
Metaclopramide
3
Q
Antiemetic
Seratonin inhibitor
A
Ondansetron and dolansetron
4
Q
Antiemetic
- NK1 receptor antagonist
- Blocks receptors in peripheral nerves, trigger zones and vomiting center
- Acute or chronic vomiting, controls post chemo vomiting
- Blocks vestibular input at higher doses
- Blocks visceral pain
A
Maropitant = Cerenia
5
Q
Gastric Ulcer Treatment Proton pump inhibitor -Irreverseably binds ATP-ase -Takes 3-5 days for max effect -Used for significant ulcer disease, or esophageal disease
A
Omeprazole and Pantroprazole
6
Q
Gastric Ulcer Treatment Antacid -Binds ulcer creating barrier -Neutralizes acid -Increased mucus synthesis, increased prostaglandin E, increased epidermal growth factor
A
Sucralfate
7
Q
Acts at seratonin receptor
- Treat GI motility, hypomotility, feline megacolon, atonic urinary bladder - Compounding pharmacy - More potent than metaclopramide
A
Cisapride
8
Q
Acts at Motilin receptor
-Upper GI motility increased, may work on canine or equine lower GI
A
Erythromycin
9
Q
Gastric Ulcer Treatment
- Block acid production
- Block H2 receptor
- Promote ulcer healing
- Competitive inhibition
A
Famotidine
10
Q
Decrease GI Motility
Opioid
-Crosses blood brain barrier–> regulated
A
Diphenoxylate = lomotil
11
Q
Decrease GI Motility Opioid -Doesn't cross blood brain barrier -Over the counter -Can be used in cats -Should not be used in collies with p glycoprotein defects
A
Loperamide = imodium
12
Q
- Antisecretory, antibacterial, anti-prostaglandin effects
- Potential toxicity in cats
- Loses taste if kept cold: refrigerate
A
Bismuth subsalicylate = pepto bismol
13
Q
Inflammatory Bowel Disease treatment
- Can cause dry eye - Works in colon
A
Sulfasalizine
14
Q
Inflammatory Bowel Disease treatment
- No dry eye - Reaches higher colonic levels than sulfasalizine
A
Olsalazine
15
Q
Laxative
-Wetting agent for material in intestine
A
DSS = dioctyl sodium
