Steroids

Question 1

Glucocorticoid

• Short duration = <12hr
• Antiinflamatory = 1
• Mineralocorticoid potency = 1
• Use topically for pruritis and inflammation from allergy

Answer 1

Hydrocortisone

Question 2

Glucocorticoid

• Intermediate duration
• Antiinflammatory = 4-5
• Mineralocorticoid = .8-.5
• Systemic use for long term management of allergy, chronic inflammation and immune suppression

Answer 2

Prednisone(pro-drug), and prednisolone(active form)

Question 3

Glucocorticoid

• Long duration
• Anti-inflammatory = 25
• No mineralocorticoid potency
• Systemic use for immediate relief of hypersensitivity and septic shock, long term control of allergy and immunosuppression

Answer 3

Dexamethasone

Question 4

Mineralocorticoid

• Long acting, up to one month
• Not much glucocorticoid action

Answer 4

Fludrocortisone acetate

Question 5

Mineralocorticoid

• 8hr half life
• Has glucocorticoid activity

Answer 5

Desoxycorticosterone pivalate(DOCP)

Question 6

Adrenal steroid inhibitor
-Cytotoxic = selectively destroys cells in adrenal gland–> reduces all adrenal steroids except aldosterone(most of the time), reduced cortisol increases response to insulin

Answer 6

Mitotane