Vascullitis Flashcards
Takayasu
where it happens?
what we will see on imaging?
what the treatment?
- aorta, branches of subclavian, carotid
- strings of beads on aortic branches
- treatment- corticosteroids
Giant cell arthritis
diagnosis and treatment
blood abnormlity
- temporal artery biopsy
- corticosteroids
- high ESR, elevated CPK
whats the diagnosis?
40Y man with hematuria, sinusitis / nasal polyps/ stridor/ mastoiditis, hemoptysis, RBC casts , +2 protenuria
which AB, Treatment
Wegener - granulomatosis with polyangitis
C-ANCA»_space; anti protienase 3
Treatment: coritcosteroids
which disease are p-ANCA positive (anti-MPO)
- Churg-Strauss (Eosinophilic granulomatosis with polyangiitis)
- Microscopic polyangiitis
What is the symptoms of Churg Strauss
Hematuria, asthma that dont go away.
personal / family history of allergies.
Treatment: Corticosteroids
Which patoghen is associated with polyarthritis nodusa (PAN)
HBV
whats the diagnosis?
Whore, high fever 3 wks, severe abdominal pain, blood in stool, HBVsAg - positive, HBcAg- positive
polyarthritis nodusa
infraction - bleeding from organs
what is the image on CT of Polyarthritis nodusa
strings of perals of vessels involve
whats the treatment for Polyarthrithis nodusa?
Corticosteroids, Cyclophosphamide
mnemonic for Kawasaki disease:
under 5 yrs of age
the CREAM BURN:
C-Conjuctuvitis (non exudative)
R- Rash (polymorphus non vasicular)
E- Edema (or erythema of hands and feet)
A- Adenopathy ( cervical , often unilateral)
M- mucosal involvment (erythema, fissures, crusting) + BURN = > 5 days of fever
how to diagnose Kawasaki?
4/5 criteria
what is the PLT count in kawasaki
Thrombocytosis 500K-1M (in late stages)
whats the treatment for kawasaki
Aspirin, IVIG
Whats the diagnosis?
30y male askhenazi , with severe pain in right great toe»_space; has autoamutated + heavy smoker
also whats the treatment? which parts always involve?
Buergers disease- Thromboangiitis obliterans
lower extrimity- always involve
Tx: Stop smoking, otherwise lower extirmity will disappear.
Goodpasture syndrome
* which Ab
* what apperance in immunoflorecence- smooth or glomerular?
* which complement will bind and what is job?
- anti-GBM (HSR II)
- smooth pattern (linear)
- C5a - chemotactic for neutrophils
whats the diagnosis?
child with palpable purpura under buttnock , joint pain, abdominal pain
which immunoglobulin is involve?
Henoch-Schonlein purpura = IgA vasculitis
which vaccine is C/I in HSP
Rotavirus ssDNA
which conditioned are c/I for rota virus ssDNA vaccineation?
- HSP
- intussuspection
- meckel’s diverticuli
whats the diagnosis?
Femlae, HCV+, storke when moved to cold area + purpura
Mixed cryoglobulinemia
what happends in Mixed cryoglobulinemia
what the treatment
IgM aggulinate at cold tempartures
Tx: underlying disease + cyclophosphamide
which conditions HCV can be a/w?
3
- mixed cryoglobulinemia
- membranoprolifarateve GN
- porphyria trada
which syndrome can meningococcal meningitis cause
waterhouse syndrome- bleeding of the adrenal vessels»_space; acute adrenal insufficiancy
