Vascullitis

Question 1

Takayasu
where it happens?
what we will see on imaging?
what the treatment?

Answer 1

1. aorta, branches of subclavian, carotid
2. strings of beads on aortic branches
3. treatment- corticosteroids

Question 2

Giant cell arthritis
diagnosis and treatment
blood abnormlity

Answer 2

1. temporal artery biopsy
2. corticosteroids
3. high ESR, elevated CPK

Question 3

whats the diagnosis?
40Y man with hematuria, sinusitis / nasal polyps/ stridor/ mastoiditis, hemoptysis, RBC casts , +2 protenuria

which AB, Treatment

Answer 3

Wegener - granulomatosis with polyangitis
C-ANCA&raquo_space; anti protienase 3
Treatment: coritcosteroids

Question 4

which disease are p-ANCA positive (anti-MPO)

Answer 4

1. Churg-Strauss (Eosinophilic granulomatosis with polyangiitis)
2. Microscopic polyangiitis

Question 5

What is the symptoms of Churg Strauss

Answer 5

Hematuria, asthma that dont go away.
personal / family history of allergies.
Treatment: Corticosteroids

Question 6

Which patoghen is associated with polyarthritis nodusa (PAN)

Answer 6

HBV

Question 7

whats the diagnosis?

Whore, high fever 3 wks, severe abdominal pain, blood in stool, HBVsAg - positive, HBcAg- positive

Answer 7

polyarthritis nodusa
infraction - bleeding from organs

Question 8

what is the image on CT of Polyarthritis nodusa

Answer 8

strings of perals of vessels involve

Question 9

whats the treatment for Polyarthrithis nodusa?

Answer 9

Corticosteroids, Cyclophosphamide

Question 10

mnemonic for Kawasaki disease:

under 5 yrs of age

Answer 10

the CREAM BURN:
C-Conjuctuvitis (non exudative)
R- Rash (polymorphus non vasicular)
E- Edema (or erythema of hands and feet)
A- Adenopathy ( cervical , often unilateral)
M- mucosal involvment (erythema, fissures, crusting) + BURN = > 5 days of fever

Question 11

how to diagnose Kawasaki?

Answer 11

4/5 criteria

Question 12

what is the PLT count in kawasaki

Answer 12

Thrombocytosis 500K-1M (in late stages)

Question 13

whats the treatment for kawasaki

Answer 13

Aspirin, IVIG

Question 14

Whats the diagnosis?
30y male askhenazi , with severe pain in right great toe&raquo_space; has autoamutated + heavy smoker

also whats the treatment? which parts always involve?

Answer 14

Buergers disease- Thromboangiitis obliterans
lower extrimity- always involve
Tx: Stop smoking, otherwise lower extirmity will disappear.

Question 15

Goodpasture syndrome
* which Ab
* what apperance in immunoflorecence- smooth or glomerular?
* which complement will bind and what is job?

Answer 15

1. anti-GBM (HSR II)
2. smooth pattern (linear)
3. C5a - chemotactic for neutrophils

Question 16

whats the diagnosis?
child with palpable purpura under buttnock , joint pain, abdominal pain

which immunoglobulin is involve?

Answer 16

Henoch-Schonlein purpura = IgA vasculitis

Question 17

which vaccine is C/I in HSP

Answer 17

Rotavirus ssDNA

Question 18

which conditioned are c/I for rota virus ssDNA vaccineation?

Answer 18

1. HSP
2. intussuspection
3. meckel’s diverticuli

Question 19

whats the diagnosis?
Femlae, HCV+, storke when moved to cold area + purpura

Answer 19

Mixed cryoglobulinemia

Question 20

what happends in Mixed cryoglobulinemia

what the treatment

Answer 20

IgM aggulinate at cold tempartures

Tx: underlying disease + cyclophosphamide

Question 21

which conditions HCV can be a/w?

3

Answer 21

1. mixed cryoglobulinemia
2. membranoprolifarateve GN
3. porphyria trada

Question 22

which syndrome can meningococcal meningitis cause

Answer 22

waterhouse syndrome- bleeding of the adrenal vessels&raquo_space; acute adrenal insufficiancy