Paraneoplastic improted

Question 1

Which molecule secreted in Squemous lung cancer that caused DI (diabetic insipudus) and in what mechanism?

Answer 1

PTHrP- High Ca levels&raquo_space; decrease ADH activity at Collecting duct&raquo_space; nephrogenic DI

Question 2

which electrolyte is influence by PTHrP

Answer 2

Calcium = Hypercalcemia

Question 3

which cancers are associated with hypercalcemia

Answer 3

squemous cell lung cancer, Multiple myeloma,

Question 4

how does MM causeing hypercalcemia

Answer 4

plasma cells produce IL-1 (Osteoclast activating factor)&raquo_space; release calcium from bone

Question 5

What is the diagnosis? 14 yr old kid with posterior fossa mass with cerebellopontine calcifications, and father died from bilateral RCC. Hematocrt 75%

Answer 5

Hemangioblastoma with EPO production

Question 6

Which tumors defines at VHL (von hippel lindau)

Answer 6

Renal clear cells, Hemangioblastoma (HCC), Pheochromocytoma

Question 7

What is the marker for HCC

Answer 7

Alpha feto-protein (Aspregillus flavus + parasiticus)

Question 8

Whats the difference in HCC between HBV to HCV

Answer 8

HBV- without chronicity, HCV- Cirrohsis&raquo_space; HCC

Question 9

which toxin produce in ______ responsible for HCC

Answer 9

Alpha-toxin

Question 10

Which tumor associated with SVC syn.

Answer 10

Thymoma, MG (must rule out Thymoma), masses in anterior mediatinum (3T’s = Tymoma, Teratoma, Terrible lymphoma)

Question 11

what are the 3T’s masses in anterior mediatinum

Answer 11

Tymoma, Teratoma, Terrible lymphoma

Question 12

In which medical ilness Thymoma must be ruled out

Answer 12

Mysthenia Gravis

Question 13

What are the post, mediastinal masses

Answer 13

Neurobastomas, Pheochromocytoma

Question 14

Whats the diagnosis? Pt with newly diagnosed Diabetes + res lesions on lower extremities (kegs&raquo_space; thighs&raquo_space; perineum)

Answer 14

Glucagonoma

Question 15

In what type of tumors there are red lesions who disappear- reapper in Centrifugal fashion, and how they called

Answer 15

Glucagonoma, Necrolytic migratory Erythema

Question 16

Whats the diagnosis- Thickened ,hyperpogmanted lesions on neck and armpit (within 3-4 weeks)

Answer 16

Acanthosis Nigricans (High insulin levels)- associated with Gastric Adenocarcinoma (IGF-II)

Question 17

Which tumor associated with Acanthosis nigricans

Answer 17

Gastric Adenocarcinoma

Question 18

When Acanthosis Nigricans will show progressivly

Answer 18

PCOS (High levels of insulens, obesity)

Question 19

Whats The diagnosis- ataxia, nystagmus, problem in producing wordsm Hx of Breast/ ovarian cancer

Answer 19

Paraneoplastic Cerebellar Deganeration

Question 20

Which Ab are produce in Paraneoplastic Cerebellar Deganeration

Answer 20

Anti- Yo/Ho

Question 21

Whats the diagnosis? Pt with weight loss + hyperpigmanted lesions on the back and upper abdomen

Answer 21

Pancreatic / Gastric Adenocarcinoma

Question 22

Whats the diagnosis? Bronchospastic symptoms, Right sided Heart problems (TR , Pulmonic stenosis)Diarrhea, Flushing

Answer 22

Carcinoid syndrome

Question 23

A pt with carcinoid syndrome can develop _______ (clue: Trypthopan)

Answer 23

Pellagra (Lack of B3- niacin)- driven tryptopan to seratonin. 3D’s- Diarrhea, Dementia, Dermatitis

Question 24

Whats the diagnosis? 3 yr old with abdominal pain, midline mass, frequent eye movment chilr rolling eyes, uncoordinated twitching of upper and lower extremity muscles

Answer 24

Neuroblastoma associated with opsoclonus- myoclonus syn.

Question 25

in the present of Dermatomyositis, which tumors should be screened for

Answer 25

Ovarian Cancer

Question 26

what is the skin presentation of dermatomyositis

Answer 26

Gottron papules + Heliotrope rash (check for ovarian cancer)