Paraneoplastic improted Flashcards
Which molecule secreted in Squemous lung cancer that caused DI (diabetic insipudus) and in what mechanism?
PTHrP- High Ca levels»_space; decrease ADH activity at Collecting duct»_space; nephrogenic DI
which electrolyte is influence by PTHrP
Calcium = Hypercalcemia
which cancers are associated with hypercalcemia
squemous cell lung cancer, Multiple myeloma,
how does MM causeing hypercalcemia
plasma cells produce IL-1 (Osteoclast activating factor)»_space; release calcium from bone
What is the diagnosis? 14 yr old kid with posterior fossa mass with cerebellopontine calcifications, and father died from bilateral RCC. Hematocrt 75%
Hemangioblastoma with EPO production
Which tumors defines at VHL (von hippel lindau)
Renal clear cells, Hemangioblastoma (HCC), Pheochromocytoma
What is the marker for HCC
Alpha feto-protein (Aspregillus flavus + parasiticus)
Whats the difference in HCC between HBV to HCV
HBV- without chronicity, HCV- Cirrohsis»_space; HCC
which toxin produce in ______ responsible for HCC
Alpha-toxin
Which tumor associated with SVC syn.
Thymoma, MG (must rule out Thymoma), masses in anterior mediatinum (3T’s = Tymoma, Teratoma, Terrible lymphoma)
what are the 3T’s masses in anterior mediatinum
Tymoma, Teratoma, Terrible lymphoma
In which medical ilness Thymoma must be ruled out
Mysthenia Gravis
What are the post, mediastinal masses
Neurobastomas, Pheochromocytoma
Whats the diagnosis? Pt with newly diagnosed Diabetes + res lesions on lower extremities (kegs»_space; thighs»_space; perineum)
Glucagonoma
In what type of tumors there are red lesions who disappear- reapper in Centrifugal fashion, and how they called
Glucagonoma, Necrolytic migratory Erythema
Whats the diagnosis- Thickened ,hyperpogmanted lesions on neck and armpit (within 3-4 weeks)
Acanthosis Nigricans (High insulin levels)- associated with Gastric Adenocarcinoma (IGF-II)
Which tumor associated with Acanthosis nigricans
Gastric Adenocarcinoma
When Acanthosis Nigricans will show progressivly
PCOS (High levels of insulens, obesity)
Whats The diagnosis- ataxia, nystagmus, problem in producing wordsm Hx of Breast/ ovarian cancer
Paraneoplastic Cerebellar Deganeration
Which Ab are produce in Paraneoplastic Cerebellar Deganeration
Anti- Yo/Ho
Whats the diagnosis? Pt with weight loss + hyperpigmanted lesions on the back and upper abdomen
Pancreatic / Gastric Adenocarcinoma
Whats the diagnosis? Bronchospastic symptoms, Right sided Heart problems (TR , Pulmonic stenosis)Diarrhea, Flushing
Carcinoid syndrome
A pt with carcinoid syndrome can develop _______ (clue: Trypthopan)
Pellagra (Lack of B3- niacin)- driven tryptopan to seratonin. 3D’s- Diarrhea, Dementia, Dermatitis
Whats the diagnosis? 3 yr old with abdominal pain, midline mass, frequent eye movment chilr rolling eyes, uncoordinated twitching of upper and lower extremity muscles
Neuroblastoma associated with opsoclonus- myoclonus syn.
in the present of Dermatomyositis, which tumors should be screened for
Ovarian Cancer
what is the skin presentation of dermatomyositis
Gottron papules + Heliotrope rash (check for ovarian cancer)
