Antibodies Flashcards
Rheumatoid Arthritis
Ab
Which one is specific and which is sensetive
Anti-RF (Sensetive)
Anti-CCP (Specefic)
Sensitivity: the ability of a test to correctly identify patients with a disease. Specificity: the ability of a test to correctly identify people without the disease. True positive: the person has the disease and the test is positive.
SLE
Ab
Which one is specific and which is sensetive
- ANA (Sensitive)
- Anti Smith
- Anti-dsDNA (Specific)
ITP
Ab
Anti-GPIIBIIIa
Anti-phospholipid syn.
Ab
- Anti-phospholipid
- anti-cardiolipin
- lupus anti-coagulant
- anti- beta2 glycoprotein
Sjoren
Ab
- Anti-ro (SSA)
- Anti-la (SSB)
Wegene’s
Ab
C-ANCA
Polyarthritis nodosa
EGPA
Microscopic polyangiitis
Which Ab defines all 3 diseases
p-ANCA
Polymyosotis
Dermatomyositis
Ab
- Anti-Jo1
- Anti-mi2
- Anti-SRP –> Screen for ovarian cancer
PBC
(Primary biliary cholangitis)
Ab
Anti-mitochondiral
Systemic scleroderma
Ab
Anti-Scl70 / Topoisomerase
CREST
Ab
Anti-centromere
less severe form of scleroderma is called limited scleroderma, or CREST syndrome.
CREST syndrome is characterized by: Calcinosis: Calcium skin deposits. Raynaud’s phenomenon.
Esopahgeal dysfunction
Sclerodactylyty
Telangiectasis
Drug induce lupus
ab
Anti-histone
Mixed CT Disease
anti- U1RNP
Post infectous glomerulonephritis
PIGN
ab
- Anti-treptolysin O
- Anti- DNASE B
DM type 1
ab
- Anti-Islet
- GAD
