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Y2 MSK > Vasculitis > Flashcards

Vasculitis Flashcards

1
Q

What is vasculitis?

A

inflammation of blood vessels which can result in wall thickening, stenosis and ischaemia

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2
Q

what are the two types of large vessel vasculitis?

A

Giant Cell Arteritis

Takayasu Arteritis

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3
Q

what subgroups can small vessel vasculitis be divided into?

A

ANCA +ve and ANCA -ve (immune complex) vasculitis

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4
Q

Give 3 types of ANCA+ve small vessel vasculitis?

A

GPA (Granulomatosis with Polyangiitis)
EGPA (Eosinophilic Granulomatosis with Polyangiitis)
MPA (Microscopic Polyangiitis)

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5
Q

Give an example of ANCA-ve small vessel vasculitis?

A

Henoch Schonlein Purpura

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6
Q

What is another name for GPA?

A

Wegner’s

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7
Q

What is GPA?

A

granulomatous inflammation involving the respiratory tract

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8
Q

What is associated with cANCA and proteinase-3?

A

GPA

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9
Q

What is associated with pANCA?

A

EGPA

MPA

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10
Q

what are some signs/symptoms of GPA?

A 
presence of cANCA/ANCA/proteinase-3
epistaxis 
nasal crusting 
casal cartilage collapse 
haemoptysis 
cavitating lesions in the lungs on X-Ray
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11
Q

What is another name for EGPA?

A

Churg-Strauss Syndrome

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12
Q

What is EGPA associated with?

A

Asthma

pANCA

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13
Q

What condition can MPA cause?

A

Glomerulonephritis

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14
Q

what is the general management of ANCA+ve small vessel vasculitis?

A

IV steroids + cyclophosphamide

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15
Q

What is Takayasu Arteritis?

A

vasculitis of the aorta and its main branches

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16
Q

Who is usually affected by Takayasu Arteritis?

A

women of childbearing age

17
Q

How does GCA usually present?

A

Unilateral headache
Jaw claudication
Scalp tenderness

18
Q

What is a potential complication of GCA?

A

loss of vision due to disruption to the blood supply to the optic nerve

19
Q

What would blood tests show in large vessel vasculitis?

A

raised ESR, plasma viscosity and CRP

20
Q

What is the gold standard investigation for GCA?

A

temporal artery biopsy

21
Q

Management of large vessel vasculitis?

A

Prednisolone 40-60mg with a reduced dose over time

22
Q

What is Henoch Scholein Purpura associated with?

A

IgA

23
Q

How does Henoch Scholein Purpura typically present

A

symptoms usually follow a URTI -> rash over buttocks and legs with vomiting and joint pain

24
Q

Management of Henoch Scholein Purpura?

A

Self-limiting

Y2 MSK (35 decks)

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