Systemic Sclerosis Flashcards
1
Q
what is systemic sclerosis?
A
multisystem autoimmune disease characterised by vascular problems, autoimmunity and fibrosis
2
Q
what is the difference between diffuse and limited systemic sclerosis?
A
limited = only below elbows and knees affected diffuse = trunk and organ involvement
3
Q
typical presentation of systemic sclerosis?
A
raynauds
sclerodactyly
difficulty swallowing
telangiectasia
4
Q
autoantibody specific to limited systemic sclerosis?
A
anti-centromere antibody
5
Q
autoantibody specific to diffuse systemic sclerosis?
A
anti-Scl-70 antibody
6
Q
management for systemic sclerosis?
A
no cure - symptomatic control
Ca2+ channel blocker for raynauds (amlodipine)
