Malignant MSK tumours

Question 1

what is the most common primary malignant bone tumour?

Answer 1

Osteosarcoma

Question 2

what cells are osteosarcomas tumours of?

Answer 2

osteoblasts

Question 3

Osteosarcoma presentation?

Answer 3

• Young male (<25 yrs)
• local swelling, pain and tenderness usually around knee
• can metastasise via blood stream
• affects metaphysis of long bones

Question 4

what treatment are osteosarcomas resistant to?

Answer 4

radiotherapy

Question 5

how are osteosarcomas managed?

Answer 5

surgery + chemotherapy

Question 6

what cells are chondrosarcomas tumours of?

Answer 6

chondrocytes

Question 7

where do chondrosarcomas tend to develop?

Answer 7

Proximal femur and pelvis

Question 8

what can be seen on X-Ray in chondrosarcomas?

Answer 8

popcorn calcification

Question 9

what treatment are chondrosarcomas resistant to?

Answer 9

radio and chemotherapy

Question 10

how are chondrosarcomas managed?

Answer 10

surgery

Question 11

What are Ewing’s Sarcomas?

Answer 11

Tumours of bone marrow, typically affecting children

Question 12

How do Ewing’s Sarcomas typically present?

Answer 12

• warm swelling associated with raised inflammatory markers and a fever
• usually young males (between age 10-20)

Question 13

Which tumour would show onion ring sign on X-Ray?

Answer 13

Ewing’s sarcoma

Question 14

Management for Ewing’s sarcoma?

Answer 14

combination of chemotherapy, radiotherapy and surgery

Question 15

what is an angiosarcoma?

Answer 15

malignancy of blood vessels

Question 16

what is a fibrosarcoma?

Answer 16

malignancy of fibrous tissues

Question 17

what is a liposarcoma?

Answer 17

malignancy arising from fat

Question 18

what is a rhabdomyosarcoma?

Answer 18

malignancy arising from skeletal muscle

Question 19

what is a synovial sarcoma?

Answer 19

malignancy of the synovial lining of joints

Question 20

What are the 5 malignant tumours that can metastasise to bone?

Answer 20

Breast 
Prostate 
Lung 
Renal cell
Thyroid