Seronegative arthropathies Flashcards
What is ankylosing spondylitis?
Chronic inflammatory disease of the spine and sacroiliac joints which leads to fusion of the intervertebral and sacroiliac joints
are males or females more commonly affected by ankylosing spondylitis?
males 3:1 females
Which gene do the majority of ankylosing spondylitis patients have?
HLA-B27
What is enthetisis?
inflammation of where tendons/ligaments insert on the bone
how does ankylosing spondylitis typically present?
Gradual onset back pain with morning stiffness that is worse at night and relieved by exercise
Gradual loss of spinal movement with development of a question mark spine
which conditions are strongly associated with ankylosing spondylitis?
enthesitis
anterior uveitis
pulmonary fibrosis
how does a question mark spine form?
loss of lumbar lordosis and increased thoracic kyphosis
what examination can be done to test spinal movement?
Schobers test
what will be seen on X-Ray in ankylosing spondylitis?
bamboo spine
fusion of sacroiliac joints
What will be seen on MRI in ankylosing spondylitis?
bone marrow oedema
enthesitis of spinal ligaments
Management of ankylosing spondylitis?
Exercise & physio
NSAIDs
anti-TNF (entanercept, adalimumab)
what is psoriatic arthritis?
inflammatory polyarthritis associated with psoriasis
management for psoriatic arthritis?
same as RA:
methotrexate -> sulfasalazine -> anti-TNF
What is enterophatic arthritis?
Inflammatory arthritis associated with IBD
Management of enterophatic arthritis?
management of IBD
what is reactive arthritis?
inflammatory arthritis which occurs as an autoimmune response to an infection elsewhere in the body (usually Gi and GU)
What are common infections that can cause reactive arthritis?
GI: salmonella, campylobacter
GU: chlamydia, niesseria
what is Reiters syndrome?
triad of symptoms in reactive arthritis - arthritis, uveitis and urethritis
management of reactive arthritis?
treat underlying infection + symptomatic relief
Sacroilitis can be a feature of enteropathic arthritis. True or false?
True - especially Crohn’s
What is dactylics a feature of?
Psoriatic arthritis
