Seronegative arthropathies

Question 1

What is ankylosing spondylitis?

Answer 1

Chronic inflammatory disease of the spine and sacroiliac joints which leads to fusion of the intervertebral and sacroiliac joints

Question 2

are males or females more commonly affected by ankylosing spondylitis?

Answer 2

males 3:1 females

Question 3

Which gene do the majority of ankylosing spondylitis patients have?

Answer 3

HLA-B27

Question 4

What is enthetisis?

Answer 4

inflammation of where tendons/ligaments insert on the bone

Question 5

how does ankylosing spondylitis typically present?

Answer 5

Gradual onset back pain with morning stiffness that is worse at night and relieved by exercise
Gradual loss of spinal movement with development of a question mark spine

Question 6

which conditions are strongly associated with ankylosing spondylitis?

Answer 6

enthesitis
anterior uveitis
pulmonary fibrosis

Question 7

how does a question mark spine form?

Answer 7

loss of lumbar lordosis and increased thoracic kyphosis

Question 8

what examination can be done to test spinal movement?

Answer 8

Schobers test

Question 9

what will be seen on X-Ray in ankylosing spondylitis?

Answer 9

bamboo spine

fusion of sacroiliac joints

Question 10

What will be seen on MRI in ankylosing spondylitis?

Answer 10

bone marrow oedema

enthesitis of spinal ligaments

Question 11

Management of ankylosing spondylitis?

Answer 11

Exercise & physio
NSAIDs
anti-TNF (entanercept, adalimumab)

Question 12

what is psoriatic arthritis?

Answer 12

inflammatory polyarthritis associated with psoriasis

Question 13

management for psoriatic arthritis?

Answer 13

same as RA:

methotrexate -> sulfasalazine -> anti-TNF

Question 14

What is enterophatic arthritis?

Answer 14

Inflammatory arthritis associated with IBD

Question 15

Management of enterophatic arthritis?

Answer 15

management of IBD

Question 16

what is reactive arthritis?

Answer 16

inflammatory arthritis which occurs as an autoimmune response to an infection elsewhere in the body (usually Gi and GU)

Question 17

What are common infections that can cause reactive arthritis?

Answer 17

GI: salmonella, campylobacter
GU: chlamydia, niesseria

Question 18

what is Reiters syndrome?

Answer 18

triad of symptoms in reactive arthritis - arthritis, uveitis and urethritis

Question 19

management of reactive arthritis?

Answer 19

treat underlying infection + symptomatic relief

Question 20

Sacroilitis can be a feature of enteropathic arthritis. True or false?

Answer 20

True - especially Crohn’s

Question 21

What is dactylics a feature of?

Answer 21

Psoriatic arthritis