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Y2 MSK > Arthritis drug side effects > Flashcards

Arthritis drug side effects Flashcards

1
Q

What 2 functions do NSAIDs have?

A

anti-inflammatory and analgesic effect

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2
Q

Give 3 examples of NSAIDS?

A

Ibuprofen
Naproxen
Diclofenac

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3
Q

What are some adverse effects of NSAIDs?

A 
Dyspepsia 
Gastritis 
Peptic ulcer
Renal impairment 
Fluid retention
Wheeze 
Rash
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4
Q

what is the goal time scale to have started DMARD therapy in rheumatoid arthritis?

A

Start on methotrexate/alternative DMARD within 3 months of onset of symptoms

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5
Q

What are the two DMARDs of choice that are used in Scotland?

A

Methotrexate

Sulfasalazine

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6
Q

Give 4 examples of DMARDs?

A

Methotrexate
Sulfasalazine
Leflunomide
Hydroxychloroquine

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7
Q

Which supplement do patients on methotrexate have to take and why?

A

Folic acid because methotrexate causes your body to excrete more folate than usual

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8
Q

What are some adverse effects of methotrexate?

A 
Thrombocytopenia (low platelets in blood)
Cirrhosis (need to limit alcohol intake)
Pneumonitis 
Nausea/diarrhoea 
Teratogenic
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9
Q

How long before conception does methotrexate have to be stopped?

A

3 months in males and females

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10
Q

What are some adverse effects of sulfasalazine?

A

Nausea
Rash/mouth ulcers
Neutropenia (low neutrophils)
Hepatitis

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11
Q

What are biologics?

A

Drugs designed to target specific parts of the immune system found to be implicated in rheumatoid arthritis - TNF, B cells, interleukin 6, 17, 12 and 23

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12
Q

Are anti-TNF therapy and biologics the same thing?

A

Yes

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13
Q

What scoring system is used to determine whether a patients condition is serious enough for the use of biologics?

A

DAS28 score

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14
Q

Give 3 examples of biologics/anti-TNFS?

A

Infliximab
Etanercept
Adalimumab

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15
Q

What are some adverse effects of biologics/anti-TNF?

A

Risk of infection increased
Risk of skin cancer increased
Exacerbation of heart failure
Reactivation of latent TB

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16
Q

What are some adverse effects of corticosteroids?

A 
Weight gain
Muscle wasting 
Skin atrophy
Osteoporosis 
Diabetes 
Hypertension
Cataracts & glaucoma 
Adrenal suppression 
Immunosuppression
Avascular necrosis of the femoral head
17
Q

Should live vaccines be given to patients who are on DMARDs?

A

No

Y2 MSK (35 decks)

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