Vasculitis

Question 1

Vasculitis can lead to what?

Answer 1

Necrosis of vessel wall with perforation and hemorrhage into adjacent tissues. Occlusion of vessel can lead to distal ischemia and infarction of tissue

Question 2

What organisms can cause infectious vasculitis?

Answer 2

Rickettsia, Syphilis, Aspergillus

Question 3

What can cause noninfectious vasculitis?

Answer 3

Autoimmune response to known pathogen such as Cryoglobulinemic vasculitis and Hep C infection

Question 4

Types of large vessel vasculitis (2)?

Answer 4

Takayasu

Giant Cell Arteritis

Question 5

Who does Takayasu present in?

Answer 5

Younger patients with clarification of extremities

Question 6

Telltale sign of Takayasu?

Answer 6

BP diff between extremities, bruit over subclavian artery/aorta

Question 7

Treatment of Takayasu?

Answer 7

High dose corticosteroids

Question 8

Giant cell arteritis presents in who?

Answer 8

Older patients > 50 with headache, visual loss, jaw claudication

Question 9

Major worry from Giant cell arteritis?

Answer 9

Blindness

Question 10

Gold standard of diagnosis for GCA?

Answer 10

Temporal artery biopsy

Elevated ESR

Question 11

Treatment for GCA?

Answer 11

High dose corticosteroid

Question 12

GCA associated with what other disease?

Answer 12

Polymyalgia Rheumatica

Question 13

What is Polymyalgia Rheumatica?

Answer 13

Sudden onset of pain and stiffness in shoulders and hips in people > 50 with high ESR

Question 14

Types of Medium Vessel Vasculitis? 2

Answer 14

Polyarteritis Nodosum

Kawasaki Disease

Question 15

Polyarteritis Nodosum (PAN) most commonly involved organ?

Answer 15

Kidney with Elevated BUN/Creatinine and Elevated BP

Question 16

Treatment for PAN?

Answer 16

High dose corticosteroids, Cyclophophamide, plasmapheresis

Question 17

Who does Kawasaki disease occur in?

Answer 17

Childhood disease, but can occur in adults

Question 18

What can Kawasaski disease lead to?

Answer 18

Coronary artery aneurysms, depressed myocardial contractility, heart failure, myocardial infarction, arrhythmia, and peripheral arterial occlusion.

Question 19

Treatment for Kawasaki?

Answer 19

IVIG within first 10 days

Aspirin

Question 20

What Small vessel vasculitis are there? (3)

Answer 20

Microscopic polyangiitis
Granulomatosis with polyangitis
Eosinophillic granulomatosis with polyangitis

Question 21

What does ANCA stand for?

Answer 21

Antibodies against Neutrophil Cytoplasmic Antigens

Question 22

What does Microscopic polyangiitis affect?

Answer 22

Lungs and Kidneys

Question 23

Lab work for Microscopic polyangiitis shows up as?

Answer 23

ANCA positive

Renal biopsy shows not granulomatous inflammation

Question 24

In Granulomatosis with polyangititis patients present with?

Answer 24

Upper and lower airway problems
Abnormal CXR
Microscopic hematuria

Question 25

GWPA labs show up as?

Answer 25

Asthma ad lung disease ANCA + | Granulomatus inflammation

Question 26

What does Eosinophilic granulomatosis with polyangiitis present as?

Answer 26

``` Asthma and lung disease Upper airway and ear disease Tender subcutaneous nodules Heart failure Thromboembolic disease Mononeuritis multiplex ```

Question 27

Labs for EGWP?

Answer 27

40-60% ANCA 5000-9000 Eosinophil Nondestruction infiltration of vessel walls by eosinophils

Question 28

Treatment for EGWP?

Answer 28

Corticosteroids, immunosuppressants

Question 29

Types of immune complex small vessel vasculitis?

Answer 29

Antiglomerular Basement Membrane Disease Cryoglobulinemic Vasculitis IgA associated Vasculitis Hypocomplementemic Urticarial vasculitis

Question 30

What does ABMD cause?

Answer 30

Glomerulonephritis Pulmonary hemorrhage Death in untreated

Question 31

Diagnosis for ABMD?

Answer 31

Kidney biopsy Anti GBM antibodies Positive ANCA

Question 32

Treatment for ABMD?

Answer 32

Plasmapheresis combined with prednisone and cyclophosphamide