Sjogren Syndrome

Question 1

What is Sjogren (Sjo) syndrome?

Answer 1

Chronic inflammatory disorder characterized by lymphatic infiltration of the exocrine glands

Question 2

Which exocrine glands are primarily infiltrated?

Answer 2

Lacrimal and Salivary

Question 3

Sjo characterized by what?

Answer 3

Dryness of eyes and mouth

Question 4

How can Sjo present?

Answer 4

By itself or combined with SLE, RA

Question 5

EtiologY?

Answer 5

Unknown, thought to be genetic with viral initiator

Question 6

What genetic bases are there for Sjo?

Answer 6

Familial tendency

Increased HLA DR3

Question 7

What viral titers have been associated with Sjo?

Answer 7

EBV, CMV, HHV6

Question 8

What is commonly found in salivary glands of Sjo patients?

Answer 8

Retrovirus HTLV-1

Coxsackie virus RNA

Question 9

Which hepatitis can cause Sjo?

Answer 9

C

Question 10

How do you diagnose ocular manifestations of Sjo?

Answer 10

Slitlamp: superficial erosions of corneal epithelium

Schirmir test:

Question 11

Systemic manifestation of Sjo?

Answer 11

Fatigue

Question 12

Neurologic manifestation?

Answer 12

Trigeminal, autonomic neuropathy

Dementia, lesions that mimic multiple sclerosis

Question 13

Lymphomas of which cell line are common?

Answer 13

B-cell line

Question 14

GI manifestations?

Answer 14

Rare malabsorption
Esophageal dysmotility
Mild pancreatitis