Tick Borne Flashcards
Organism behind Lyme disease?
Borrelia burgdorferi
Vector for lyme disease>
Deer tick
Organism behind RMSF?
Rickettsia rickettsii
Vector for RMSF?
Dog Tick
Organism behind ehrlichiosis?
Ehrlichia chafeensis
Vector for Ehrlichiosis?
Lone star tick
Stage 1 of Lyme disease?
Localized rash 3-32 days
Stage 2 of Lyme disease?
Disseminated, cranial neuritis, skin lesions, meningitis
Stage 3 Lyme disease?
Knee joint arthritis, encephalopathy, polyneuropathy, acrodermatitis
Causes of CN 7 palsy?
Idiopathic (Bell’s Palsy), Herpes simplex virus (no rash), Herpes Zoster (vesicles in external auditory canal), and Lyme disease
What will you see in Chronic Lyme Disease?
Pain syndrome, chronic fatigue, and neurocognitive symptoms
Treatment of Lyme Disease?
Doxycycline
How to you test for LD?
IgM and IgG serologic testing
What vaccines are there for LD?
None for humans, canine vaccine is available
What in the body does RMSF ticks go for?
Vascular endothelial cells
Pathophysiology of RMSF?
Vasculitis, Hypoatremia, and thrombocytopenia
Classic triad of RMSF?
Fever, rash, and history of tick exposure
How does the rash progress?
Starts as merciless, progresses to vasculitic rash involving palms and soles with petechiae
What lab tests are done to diagnose RMSF?
Thrombocytopenia (low platelets)
Hypoatremia (low sodium)
What tests can you do to test for RMSF?
Skin biopsy of lesion and serologic testing of IgM and IgG
How do you treat RMSF?
Doxy except in pregnant women then use chloramphenicol
What makes adult female of lone star tick easy to distinguish?
Big white spot
Incubation period of Ehrlichiosis?
8 days
Symptoms of Ehrlichiosis?
Fever, headache, myalgia
What lab findings will you see in Ehrlichiosis?
Leukopenia, thrombocytopenia, and elevated transaminases
How do you treat Ehrlichiosis?
Doxy
What causes Malaria?
Plasmodium species
What vector causes Malaria?
Anopheles mosquito
Which Plasmodium cause the most severe disease?
P. Falciparum
What do Plasmodium sporozoites target?
Hepatocytes
What causes hemolytic anemia in Malaria?
Lysing of RBC and release of merozoities to infect more
Which strains can produce dormant hypnozoities?
Vivax and ovale
What signs suggest Falciparum?
Seizures
What signs suggest vivid or ovale?
Paroxysmal chills, fever, rigors
What should turn your diagnosis away from Malaria?
Rash
What do thin and thick blood smears allow for?
Evaluation of ring forms and estimation of parasite load
What does thick blood smear do?
Concentrates parasites and increases diagnostic sensitivity
How do you treat non-falciparum malaria?
Chloroquine
How do you treat Falciparum?
Chloroquine if sensitive, Arteminsin preferred if Chloro is questioned
Why don’t you use Mefloquine for prophylaxis
CNS side effects