vasculitic syndromes Flashcards

1
Q

Raynaud phenomenon- Eti

A

Paroxymal digital ischemia, exaggerated response of arterioles to stress or cold

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2
Q

Raynaud phenomenon- Primary V Secondary

A

Primary- appears between 15-30 in women, mildly progressive.
symmetric involvement, spasms, no digital pitting, ulceration or gangrene
Secondary- unilateral, pitting & ulceration, gangrene of digits

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3
Q

Raynaud phenomenon- Sx

A

Paroxysmal bilateral digital pallor & cyanosis followed by rubor, paresthesia, pain and swelling

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4
Q

Raynaud phenomenon Dx

A

RF serology

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5
Q

Raynaud phenomenon- Tx

A

Calcium channel blockers- nifedipine or amlodipine

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6
Q

Giant Cell Arteritis- Eti

A

> 50 yrs old, more common in N. Europeans

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7
Q

Giant Cell Arteritis- Sx

A

Pain and stiffness in shoulder and pelvic girdle, fever, malaise, weight loss, headache, jaw claudication, visual abnormalities

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8
Q

Giant Cell Arteritis- Dx

A

Elevated ESR, temporal artery biopsy

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9
Q

Giant Cell Arteritis- Tx

A

High dose predinsone, aspirin

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10
Q

Takayasu arteritis- Eti

A

granulomatous vasiculitis of aorta and major branches. Women during reproductive years, Prevalent in far east. Large vessel vasculties

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11
Q

Takayasu arteritis- Sx

A

Absent pulse, Bruits, limb claudication, unequal BPs, FUO

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12
Q

Takayasu arteritis- Dx

A

MRI- inflammatory thickening of vessel walls or CT- stenosesis, occlusions

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13
Q

Takayasu arteritis- Tx

A

Corticosteroids- x months

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14
Q

Polyarteritis nodosa- Eti

A

Medium sized artery necrosis, confined to arterial vasculature, associated with Hep B

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15
Q

Polyarteritis nodosa- Sx

A

Constitutional symptoms, pain in extremities, vasculitic nephropathy, malleoli ulcerations

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16
Q

Polyarteritis nodosa- Dx

A

Tissue biopsy

17
Q

Polyarteritis nodosa- Tx

A

High dose gluccocorticoids

18
Q

ANCA- Eti

A

Small vessel vasculitis. Glomerulonephritis due to antinuclear antibodies- autoimmune disorder

19
Q

ANCA- Sx

A

Systemic inflammatory symptoms- fever, malaise, weight loss, hematuria, protienuria, hemoptysis

20
Q

ANCA- Dx

21
Q

ANCA- Tx

A

High dose corticosteroids

22
Q

Behcet syndrome- Eti

A

Onset around 25-35, rare in N America, prevalent in Asia. Small vessel vasculitis

23
Q

Behcet syndrome- Sx

A

Recurrent oral and genital ulcers, seronegative arthritis, eye abnormalities- blindness, follicular rash, palsies- CNS involvement

24
Q

Behcet syndrome- Dx

25
Q

Behcet syndrome- Tx

A

Colchicine, Corticosteroids

26
Q

Wegener granulomatosis- Eti

A

Small vessel vasculitis. 4th-5th decade of life. Develops over 4-12 months

27
Q

Wegener granulomatosis- Sx

A

Triad: Upper & lower respiratory tract disease, and glomerulonephritis.Fever malaise & weight loss.

28
Q

Wegener granulomatosis- Dx

A

ANCA antibodies, proteinuria, tissue biopsy

29
Q

Wegener granulomatosis- Tx

A

Cyclophosphamide + oral prednisone, methotrexate