Pharm- Gout

Question 1

Colchicine-Indications

Answer 1

Reduces frequency and pain of acute gout attacks. Must be administered within 24-48 hrs

Question 2

Colchicine- MOA

Answer 2

Decreases migration of granulocytes, blocks cell division and inhibits release and synthesis of leukotrienes

Question 3

Colchicine- AE

Answer 3

N/V/ abd pain, diarrhea, neutropneia, aplastic anemia

Question 4

Xanthine oxidase inhibitors- (Allopurinol)- Indications

Answer 4

Primary hyperuricemia of gout and hyperuricemia secondary to other conditions

Question 5

Xanthine oxidase inhibitors- (Allopurinol)- MOA

Answer 5

Competitively inhibits uric acid biosynthesis

Question 6

Xanthine oxidase inhibitors- (Allopurinol)- AE

Answer 6

Hypersensativity reactions, GI

Question 7

Ucosurics (Probenecid)- Indications

Answer 7

Gout

Question 8

Ucosurics (Probenecid)- MOA

Answer 8

Promotes renal clearance of uric acid- inhibits anion exchanger in proximal tubule

Question 9

Ucosurics (Probenecid)- AE

Answer 9

HA/N/V anemia, dizziness

Question 10

Renal function & gout

Answer 10

Maintain serum urate at 6.0mg/dL or less- precipitated crystals will dissolve and clear.
6.8mg/dL and above will only slow progression.
Allopurinol agent of choice