Seronegative spondyloarthropathies

Question 1

Reactive arthritis- Eti

Answer 1

HLA-B27 positive, following dysentary or STD, manifests with oligoarthritis, conjunctivitis, urethritis & mouth ulcers. More common in men

Question 2

Reactive arthritis- Sx

Answer 2

Asymmetric large weight bearing joints. Systemic symptoms, sacroilitis, ankylosing spondylitis,

Question 3

Reactive arthritis- Dx

Answer 3

HLAB27 test

Question 4

Reactive arthritis- Tx

Answer 4

NSAID, TNF, methotrexate

Question 5

Psoriatic arthritis- Eti

Answer 5

Preceded by psoriasis, more common in severe skin disease

Question 6

Psoriatic arthritis- Sx

Answer 6

Sausage appearance of fingers, DIP involvement, psoriasis patch, nail pitting

Question 7

Psoriatic arthritis- Dx

Answer 7

Elevated ESR, seronegative RF, pencil in cup radiographic findings, asymmetric sacrolilitis

Question 8

Psoriatic arthritis- Tx

Answer 8

NSAIDs, Methotrxate, TNF,

Question 9

Ankylosing spondylitis- Eti

Answer 9

Onset in teens to 20s, greater incidence in males,

Question 10

Ankylosing spondylitis- Sx

Answer 10

Pain & stiffness improves with activity, gradual onset of back pain, limited ROM, may radiate to periphery

Question 11

Ankylosing spondylitis- Dx

Answer 11

Lab: Elevated ESR, seronegative RF, HLA-B27,
Imaging: Sclerosis of SI, bamboo spine

Question 12

Ankylosing spondylitis- Tx

Answer 12

NSAIDs, TNF inhibitors