Seropositive Spondyloarthropathic Disorders:

Question 1

Rheumatoid arthritis- Eti

Answer 1

Chronic, systemic inflammatory disease of unknown cause, females in 4th - 5th decade

Question 2

Rheumatoid arthritis- Sx

Answer 2

Morning stiffness, small joints- PIP, MCP, wrist, synovitis with pannus formation, rheumatoid nodules, monoarticular -> symmetric

Question 3

Rheumatoid arthritis- Dx

Answer 3

Anti-CCP Abs, RF, Arthrocentesis

Question 4

Rheumatoid arthritis- Tx

Answer 4

Methotrexate, TNF inhibitors, NSAIDs, DMARDs,

Question 5

Systemic lupus erythematosis- Eti

Answer 5

Young women, black women, inflammatory autoimmune disorder, multi system involvement,

Question 6

Systemic lupus erythematosis- Sx

Answer 6

Butterfly rash, alopecia, joint symptoms, ocular manifestations

Question 7

Systemic lupus erythematosis- Dx

Answer 7

Criteria guidelines

Question 8

Systemic lupus erythematosis- Tx

Answer 8

NSAIDs, topical corticosteroids, cyclophosphamide

Question 9

Scleroderma- Eti

Answer 9

Rare, chronic disorder, women in 3rd to 5th decade

Question 10

Scleroderma- Sx

Answer 10

Thickening & hidebound of skin, watermelon stomach, esophageal abnormality, can’t open mouth fully ulceration of fingertips, polyarthalgia, dysphagia, cardiac abnormalities

Question 11

Scleroderma- Dx

Answer 11

Antinuclear antibodies, scleroderma antibody

Question 12

Scleroderma- Tx

Answer 12

Symtomatic & supportive of associated symptoms- CA channel bluchers, proton pump inhibitors, etc.

Question 13

Antiphospholipid antibody syndrome- Eti

Answer 13

Often in combination of SLE, acquired, circulating Abs

Question 14

Antiphospholipid antibody syndrome- Sx

Answer 14

DVT, hypercoaguability, arterial disease, Strok, TIA, multiple pregnany loss

Question 15

Antiphospholipid antibody syndrome- Dx

Answer 15

Antiphospholipid antibodies combined with thrombosis or pregnancy morbidity

Question 16

Antiphospholipid antibody syndrome- Tx

Answer 16

Anticoagulation

Question 17

Sjogren syndrome- Eti

Answer 17

Systemic autoimmune disorder, can occur in conjunction of RA, predominantly affects women, between 40-60

Question 18

Sjogren syndrome- Sx

Answer 18

Grain of sand in eye- ocular burning, itching, ropy secretions, enlarged parotid glands, dry mouth

Question 19

Sjogren syndrome- Dx

Answer 19

RF, antibodies, lip biopsy

Question 20

Sjogren syndrome- Tx

Answer 20

Cyclosporine, prednisone, artificial tears