Metabolic bone diseases

Question 1

Osteoporosis- Eti

Answer 1

Women, middle life and on, increased rate of bone resorbtion, causes 2 million fractures annually- mostly spine & hip[

Question 2

Osteoporosis- Sx

Answer 2

Loss of height, asymptomatic until fracture, back pain to spontaneous fracture or collapse of vertebrae

Question 3

Osteoporosis- Dx

Answer 3

Dexa scan, Normal calcium & phosphate, Vit D deficieny

Question 4

Osteoporosis- Tx

Answer 4

Ca & Vit D, bisphosphonates

Question 5

Osteomalacia- Eti

Answer 5

Rickets- defective mineralization in children, Osteomalacia- in adults due to Vit D deficiency. Women & elderly

Question 6

Osteomalacia- Sx

Answer 6

Bone pain, proximal muscle weakness (pelvic girdle), pathologic features without trauma

Question 7

Osteomalacia- Dx

Answer 7

Bone densitometry, x-ray, elevated alkaline phosphate,

Question 8

Osteomalacia- Tx

Answer 8

Vitamin D, calcium supplements.

Question 9

Paget disease of bone- Eti

Answer 9

Unknown cause, genetics, british ancestry, men, over 40

Question 10

Paget disease of bone- Sx

Answer 10

Asymptomatic, pain, bowed tibias, kyphosis, fracture with slight trauma, increased vascularity

Question 11

Paget disease of bone- Dx

Answer 11

Serum alkalane phosphatase elevated, dense & expanded bone radiographs, fissures

Question 12

Paget disease of bone- Tx

Answer 12

Oral bishphosphonates