Vascular Foundations 2 Flashcards
How is blood flow maintained during ventricular diastole
elastic recoil of the arteries sends blood forward into the rest of the circulatory system
Minimum Mean Arteriole Pressure
60 mmhg
- required to perfuse the systemic organs (nutrient dilivery etc)
Pulse Pressure Equation
Systolic Pressure - Diastolic Pressure
Mean Arterial Pressure (MAP) Equation
DIastolic pressure + (1/3)*(pulse pressure)
MAP is determined by
- Blood Volume
- Cardiac Output
- Resistance
- Distribution of blood between venous and arterial vessels
Blood Volume Determinents
- Fluid intake
- Fluid loss (which depends on kidney regulation and passiveness)
Cardiac Output Determinents
- Heart Rate
- Stroke Volume
Resistance Determinents
- arteriole diameter
Distribution of blood determinents
- diameter of the veins
Arteriole Resistance determination
arteriolar radius, which can be changed by
1. local factors
2. SNS
Local Factors of Radius Change
- Myogenic Autoregulation
- Paracrines released in response to changes in tissue needs
Myogenic Autoregulation
reflexive constriction of the blood vessel in response to an increased pressure
- decreases blood flow/pressure
- increases contraction and resistance
Paracrines released in response to changes in tissue needs types
- Active Hyperemia
- Reaction Hyperemia
Active Hyperemia
matching flow to metabolic demand
EX) increased demand will lead to increased blood flow by vasodilation
Reactive Hyperemia
compensation following a period of reduced blood flow
EX) decreased blood flow due to blocked leads to vasodilation to increase blood flow and move the blockage
SNS affect on Arteriole Resistance
SNS exerts tonic control with two neurotransmitters
1. Norepinephrine
2. Epinepherine
Norepinepherine Pathway on arteriole resistance
- binds to alpha-1 adrenergic receptors on most smooth muscle cells
- coupled to Gq proteins that activate PLC
- results in increased IP3
- increased Ca release from SR
- Smooth muscle contraction
Norepinepherine Overall Effect
increases contraction and diverts the blood flow away from skin/visceral organs
Epinepherine Pathway on arteriole resistance
- binds to beta-2 adrenergic receptors on smooth muscle cells of the skeletal muscles/heart/liver
- coupled to Gs protein AC
- increases cAMP and PKA
- Smooth muscle relaxation
Epinepherine Overall Effect
increases relaxation and diverts the blood flow towards the heart/lungs/liver
baroreceptors function
pressure sensors with stretch activated channels
-maintains arterial pressure homeostasis
baroreceptors location
- carotid sinus
- aortic arch