Vascular aneurysms Flashcards
At what diameter does an abdominal aneurysm occur?
> 1.5 times normal
>3 cm
where do most AAA occur?
infra renal
true or false
most AAA are true aneurysms
True
what layers are usually involved in pseudo aneurysms?
adventitia
connective tissue
what are the 4 main etiologies of AAAs?
Degenerative
Inflammatory
Traumatic
Infections
how do degenerative AAA form?
atherosclerotic AAA
associated w/matrix metalloproteinases
where are matrix metalloproteinases in the vessel of degenerative aneurysm?
the media
how to inflammatory AAA form?
exaggerated inflammation leading to fibrotic reaction around the aneurysm the can encase the surrounding structures
what are inflammatory AAAs associated with?
ureteral obstruction
how are infectious AAAs formed?
may be caused by primary infection of arterial wall or foreign bodies (prior vascular repair)
what bacteria are associated w/infectious AAAs
Salmonella Staph Candida Aspergillus Mycobacterium tuberculosis Treponema pallidum
what are the biggest RFs for AAA development?
smoking increased age (over 70) male family hx concurrent aneurysms HTN HLD CAD
what are 2 protective factors for AAA
diabetes
DVT
what are risk factors for rupture?
female decreased FEV1 large initial aortic diameter current smoker uncontrolled HTN
at what diameter does risk for rupture exponentially increase?
5.0 cm (1-11%)
what is the screening recommendation for AAA
U/S screening in men or women 65-75 years w/hx of tobacco use
or
U/S screening in first degree relative of Pts w/AAA, do at age 65-75 or 75 and older and in good health
is there a higher incidence of peripheral aneurysms in those with AAA?
yes
How can AAAs cause distal ischemic symptoms
atheroembolism
acute thrombosis of AAA can cause acute lower body ischemia (very rare)
what is the best imaging test for AAA?
U/S
almost 100% sensitivity and specificity
not good for detecting rupture
what SBP is the goal for a ruptured AAA?
70-90 mmHg
permissive hypotension
when do you repair a AAA besides rupture?
diameter > 5.5 cm
> 5 mm growth in 6 months or >1 cm growth in 1 year
symptomatic abdominal pain (emergent repair)
signs of embolism
mycotic aneurysm
what is a relative indication for repair?
saccular AAA
what are the disadvantages of endovascular repair?
higher rate of reintervention need long term follow up and imaging no difference in mortality rate 2-3 years after intervention high cose not for everyone