UWORLD vitamins Flashcards
A research scientist cultures hepatocytes in a growth media enriched with glutamate labelled with nitrogen isotopes. After some time, he finds that the nitrogen isotopes are transferred to oxaloacetate forming aspartate jn the process. What is the co-factor of this reaction?
Pyridoxine (B6)
Acquired Sideroblastic Anemia can be due to the possible of deficiency of which 2 subtances?
Vitamin B6 deficiency causes Sideroblastic Anemia,
Copper Deficiency can also cause Sideroblastic anemia.
Which two drugs cause peripheral neuropathy due to pyridoxine deficiency?
Isoniazid, OCPs.
Which enzyme in heme synthesis needs B6 as a co-factor, and how will it manifest if there’s a deficiency of this B6?
ALA Synthase Enzyme needs B6 as a co-factor.
Deficiency of Vitamin B6 causes acquired sideroblastic anemia
Niacin Deficiency causes a decrease in which of the enzymes?
Any enzyme that requires NAD+ will decrease due to Niacin Deficiency.
Such as,
In TCA cycle—-> isocitrate dehydrogenase, Alpha-Ketodehydrogenase, Malate dehydrogenase.
Which 2 vitamines are absorbed in small and large intestines via sodium-dependent multivitamin transporter?
B5 and B7
B6 absorption occurs in jejenum and the ileum by _____________ diffusion.
PASSIVE
Iron is absorbed predominantly where?
Duodenum and Proximal Jejenum.
The deficiency of which vitamin causes squamous metaplasia to keratinized epithelium?
Give two examples?
Vitamin A deficiency.
Squamous metaplasia of corneal epithelium into keratinized epithelium causes bitot’s spots.
Squamous metaplasia of pancreatic duct lining with areas of keratinization are seen in patients of CF.
Other name for Vitamin B7?
Biotin
Tin man entering Bee heaven
Enzymes that use B7 as co-factor?
Acetyl CoA carboxylase
Propinonoyl CoA carboxylase
Pyruvate Carboxylase
Vitamin B7 deficiency signs and symptoms?
Diarrhea, alopecia, dermatitis
2 causes of Biotin deficiency?
Raw egg whites, antibiotic use
