Intranuclear Inclusions

Question 1

HIV associated esophagitis caused by which pathogen shows eosinophilic intranuclear inclusions?

Answer 1

HSV-1 causing eosinphilic intranuclear inclusions (Cowdry Type A) in multinuclear squamous cells at ulcer margins.

Endoscopically it shows——-> smalls vesicles turning into PUNCHED OUT ulcers
(hercules in Sketchy HSV is punching in the air)

Question 2

Owl eye intranuclear inclusions seen in?

Answer 2

Infected cells in CMV (HHV5)

enveloped double stranded DNA virus