Cytoplasmic inclusions Microscopy. Flashcards

1
Q

Negri bodies? hippocampal

A

Seen in Rabies.

Cytoplasmic inclusions seen in purkinje cells of cerebellum and in hippocampal neurons.

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2
Q

Tenofovir Nephrotoxicity

A

Intracytoplasmic inclusions are that of SWOLLEN MITOCHONDRIA.

Tenofovir damages Mitochondrial DNA of PCT cells.

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3
Q

Reticulate bodies seem on Giemsa or flourascent antibody-stained smear?

A

Cytoplasmic inclusions in chlamydia are actually called reticulate bodies

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4
Q

Monocytes with Morulae

Morulae are the name for mulberry-like intracytoplasmic inclusions.

A

Seen in Ehrlichiosis

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5
Q

Amorphous densities seen in irreversible cell injury.

A

Basically are inclusions in mitochondria

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6
Q

Mallory bodies

A

Intracytoplasmic inclusions of damaged keratin filaments seen in alcoholic hepatitis

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7
Q

Bone marrow analysis of multiple myeloma shows intracytoplasmic inclusions containing ____________

A

IgG

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8
Q

Myeloperoxidase positive cytoplasmic inclusions seen in ________

A

Subtype APL of AML

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9
Q

Lewy bodies seen in ______________ are intracellular eosinophillic inclusions of _______________.

A

Parkinson’s disease, alpha-synuclein

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10
Q

What kind of inclusions are seen in frontotemporal dementia?

A

Inclusions of hyperphosphorylated Tau protein ( round pick bodies)
Or ubiquitinared TDP-43

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11
Q

Reinke crystals?

A

Seen in Leydig Cell Testicular tumour.

Reinke crystals are eosinophillic inclusions

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12
Q

Giant B cells with bilobed nuclei with owl’s eye inclusions?

A

Reed Sternberg cells seen in Hodgekin’s Lymphoma

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13
Q

Rosenthal fibres

A

Seen in pilocytic astrocytoma——-> eosinophilic intracytoplasmic inclusions.

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14
Q

What kind of inclusion sare seen in Chediak-Hegashi Syndrome?

A

Giant Cytoplasmic Granules/ Giant Lysosomal inclusions in neutrophils visible on light microscopy of peripheral Blood smear.

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15
Q

Rod-shaped cytoplasmic inclusions?

A

Called kitenoplasts—> seen in leishmaniasis.

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16
Q

What is seen in I-cell disease?

A

Intracytoplasmic inclusions in FIBROBLASTS.