Macrophages-specific Findings.

Question 1

Gaucher Disease, what is the appearance of macrophages?

Answer 1

Gaucher cells are basically lipid-laden macrophages resembling crumpled tissue paper.

Question 2

Neimann-pick disease?

Answer 2

Foam cells which are actually lipid-laden macrophages.

Question 3

Which part of LN contains macrophages?

Answer 3

Medulla.

Question 4

Where are macrophages found in spleen?

Answer 4

The marginal zone in between red pulp and white pulp.

Question 5

What is the main cell surface protein for macrophages?

Answer 5

CD 14

Question 6

Which pathogen can survive in macrophages in reticuloendothelial system?

Answer 6

Brucella

Question 7

In which disease, the macrophages are filled with the causative organisms?

Answer 7

Histoplasmosis

Question 8

How do you diagnose Leshmenia spp?

Answer 8

Macrophages containing amastigotes

Question 9

What is the relation of acute phase reactants with macrophages?

Answer 9

Hepcidin increases because of iron sequestration by macrophages.
Transferrin decreased because it is internalized my macrophages to sequester iron.

Question 10

What post-infarction complication occurs die to macrophages?

Answer 10

Interventricular septal rupture.

Question 11

Pulmonary edema?

Answer 11

Hemosiderin-laden macrophages/HF cells seen in lungs.

Also seen in the setting of alveolar hemorrhage

Question 12

Rheumatic Fever on heart biopsy?

Answer 12

Anitschkow cells (enlarged macrophages with ovoid, rod-like wavy nucleus)

Question 13

Whipple’s disease?

Answer 13

PAS+ macrophages in lamina propria.

Question 14

Immune Thrombocytopenia mechanism of disease?

Answer 14

Splenic macrophages phagocytose platelets.

Question 15

Burkitt Lymphoma’s appearance under microscope?

Answer 15

Sheets of lymphocytes with interspersed “tangible body” macrophages

Question 16

Hemophagocytic lymphohistiocytosis?

Answer 16

Bone Marrow Biopsy will show macrophages phagocytosing bone marrow elements.

Question 17

What is the origin of macrophages?

Answer 17

Mesoderm

microglial cells are also of mesodermal origin

Question 18

When are macrophages seen in ischemic brain disease/stroke biopsy?

Answer 18

3-5 days after the event.

Question 19

Chronic Pyelonephritis’ subtype xanthogranulomatous pyelonephritis on biopsy?

Answer 19

Macroscopically, orange nodules are seen.

Microscopically, foamy macrophages are seen with widespread kidney damage.

Question 20

Breast Milk contains which two types of immunity cells?

Answer 20

Macrophages and Lymphocytes

Question 21

Sarcoidosis and Macrophages story?

Answer 21

Sarcoidosis causes Hypercalcemia, and increased ACE levels due to INCREASED 1-alpha hydroxylase-mediated Vitamin D activation in macrophages.

Question 22

Macrophages laden with carbon in which disease?

Answer 22

Pneumoconiosis

Question 23

Silicosis ka pathogenesis?

Answer 23

Macrophages upon exposure to silica release fibrogenic factors leading to fibrosis.
Silica also disrupts phagolysosomes and impairs macrophage function making it more susceptible to TB.