Mitochondria Key Word.

Question 1

Anti-Mitochondrial Antibodies are seen in?

Answer 1

Primary Bililary Cholangitis.

Question 2

Problem in a gene that encodes for iron-binding protein that leads to impaired mitochondrial functioning?

Answer 2

Friedreich’s ataxia.

Question 3

Large eosinophilic cells with abundant

mitochondria without perinuclear clearing, is the histopathology of which tumour?

Answer 3

Renal Oncocytoma, that presents as painless hematuria, flank pain and abdominal mass.

Question 4

Mitochondrial DNA is _________ in shape, and does not utilize ________.

Answer 4

Circular in shape, and doesn’t utilize histones.

Question 5

Exception of Genetic code being universal in humans?

Answer 5

Mitochondria.

Question 6

Variable expression in mitochondrially inherited disease is due to?

Answer 6

Heteroplasmy.

Question 7

Which fat (Brown or white) has more mitochondria in it?

Answer 7

Brown

Question 8

Why can’t RBCS utilize ketones?

Answer 8

They lack mitochondria.

Question 9

Reye’s syndrome pathophysiology?

Answer 9

Aspirin metabolites inhibit β-oxidation
by reversible inhibition of mitochondrial
enzymes.

Question 10

Ringed sideroblasts are basically?

Answer 10

Perinuclear mitochondria with
excess iron (forming ring in
ringed sideroblasts.