uterus Flashcards
asherman syndrome
amenorrhea secondary to over-agressive curettage that destroys the basalis layer of the endometrium
anovulatory cycle
lack of ovulation leads to early bleeding due to lack of progesterone support
diagnosis of chronic endometritis requires the presence of; may result in
plasma cells; infertility
3 theories of endometriosis
retrograde menstruation*
metaplastic
lymphatic spread
most commonly involved site of endometriosis
ovary= chocolate cyst
endometriosis = increased risk of (2)
carcinoma at involved sites
clear cell tumor of ovary
endometrial hyperplasia is due to
unopposed estrogen
what is the most important risk factor for progression of endometrial hyperplasia to carcinoma
presence of atypia
leiomyoma are __ dependent, consequences
estrogen; will enlarge during pregnancy/cycles and atrophy after menopause
m/c site for leiomyoma
intramural
leiomyosarcoma, gross findings
necrosis and hemorrhage
most common cancer of female genital tract
endometrial CA
2 pathways of endometrial CA
hyperplastic (75%)
sporadic (25%)
associations with hyper plastic pathway
arises from pre-existing hyperplasia associated with unopposed estrogen PTEN mutation endometrioid spreads locally
associations with sporadic pathway
no precursor
p53 mutations
psammoma bodies
more aggressive
