Nephritic Flashcards
characteristics of nephritic syndrome
inflammation and bleeding with: less than 3.5 g/day protein, salt retention/periorbital edema/HTN, azotemia, RBC casts
what is the underlying cause of nephritic syndrome?
immune complexes activate complement,
C5a attracts neutrophils,
Neutrophils mediate damage
typical onset of post-infectious GN
2-3 weeks after infection
microscopic findings in PIGN
EM: subepithelial humps
presentation of IgA nephropathy
hematuria 1-2 days after the onset of mucosal infection
microscopic findings in IgA nephropathy
EM: immune complexes in mesangium
If: IgA in mesangium
defect in Alport syndrome
defect in type IV collagen
triad in alport syndrome
hematuria, ocular defects, SN hearing loss
most common type of renal disease in SLE
type IV- diffuse proliferative
only type of RPGN that has linear IF
Goodpasteur
Good pasteur: defect, symptoms, common patient
anti-glomerular BM antibodies
affects lung and kindey
young males
what is the characteristic LM finding for RPGN? composition? prognosis?
cresents (fibrin and macrophages), presence = poor prognosis
location of deposits in DPGN
subendothelial
granular IF (2)
post infectious GN
diffuse proliferative GN
Pauci immune GN (3)
Wegners, Microscopic polyangiitis, Churg-straus
