cervix

Question 1

ectocervix vs endocervix

Answer 1

ecto- nonkeratinizing squamous
endo- columnar
junction= transformation zone

Question 2

2 common benign findings on cervical exam

Answer 2

nabothian cysts, ectropion

Question 3

acute vs chronic cervicitis

Answer 3

acute- usually postpartum, staph or strep

chronic- m/c chalmydia

Question 4

HPV likes to infect the-

Answer 4

transformation zone

Question 5

HPV E6 protein

Answer 5

affects p53 function, allows damaged cells to progress G1-S

Question 6

HPV E7 protein

Answer 6

removes Rb, increasing free E2F, allowing progression G1-S

Question 7

characteristic HPV infected cell

Answer 7

Koilocyte

Question 8

CINs (4)

Answer 8

CIN I- under 1/3, 66% regress
CIN II- under 2/3, 33% regress
CIN III- under full, unlikely to regress
CIS- full, will not regress

Question 9

common cause of death in advanced cervical cancer

Answer 9

hydronephrosis with post-renal failure due to local invasion

Question 10

3 top risk factors for cervical cancer

Answer 10

HPV infection, smoking, immune deficiency

Question 11

somatic mutation associated with cervical cancer

Answer 11

LKB1 (Peutz-Jeghers)

Question 12

HPV vaccine covers-

Answer 12

6,11,16,18