Urogenital

Question 1

Finasteride

Answer 1

• 5 alpha reductase inhibitor- selective for type 2 alpha reductase- inhibits T- DHT in prostate, liver, skin; also male pattern balding
• BPH
• Pregnancy category X

Question 2

Doxazosin

Answer 2

• alpha 1a antagonist- non selective

- BPH, HTN

Question 3

Terazosin

Answer 3

• alpha 1a antagonist- non selective

- BPH, HTN

Question 4

Tamsulosin

Answer 4

• alpha 1a antagonist- selective- antagonized contraction of GU sm muscle
• BPH, HTN
• AE- urticaria, angioedema, resp sx, retrograde ejaculation

Question 5

Phenazopyridine

Answer 5

• Analgesic
• Urinary pain, burning, urgency, frequency
• useful with abx for uti, post- catheter, first line for IC
• AE- deep orange urine, stains on contact

Question 6

Nitrofurantoin

Answer 6

• Abx
• Cystitis, uncomplicated UTI, **E- coli, disrupts DNA ribosomal proteins, cell resp, pyruvate metabl
• Do NOT use at the end of pregnancy or during lactation

Question 7

Botulinum toxin

Answer 7

• Blocks Ach release
• OAB, chronic migraine, spasticity, hyperhidrosis
• BLACK BOX- distant toxin spread (hours to weeks)

Question 8

Tolterodine

Answer 8

• Anticholinergic- selective for muscarinic receptors
• urgency, frequency, leakage, urge incontinence, dysuria
• AE- GI upset, dry mouth, urinary retention
• CI- narrow angle glaucoma, gastric urinary retention

Question 9

Solifenacin

Answer 9

• Anticholinergic- selective for muscarinic receptors
• urgency, frequency, leakage, urge incontinence, dysuria
• AE- GI upset, dry mouth, urinary retention
• CI- narrow angle glaucoma, gastric urinary retention

Question 10

Oxybutynin

Answer 10

• Anticholinergic- selective for muscarinic receptors
• urgency, frequency, leakage, urge incontinence, dysuria
• AE- GI upset, dry mouth, urinary retention
• CI- narrow angle glaucoma, gastric urinary retention

Question 11

Bethanechol

Answer 11

• Cholinergic agonist, parasympathetic mimetic

- Acute post op and post partum non obstructive urinary retention, neurogenic atony

Question 12

Alprostadil

Answer 12

• PGE1 inhibitor, vasodilation with PLT inhibition, injected into corpus cavernosum or urethral suppository
• Any type of ED, neonates with PDA
• Pregnancy category X

Question 13

Testosterone

Answer 13

• Prostaglandin
• Many routes of admin, caution with tranfer to partner/kids
• BLACK BOX- pelosis hepatitis, LV cell tumors

Question 14

Sildenafil

Answer 14

• PDE-5 inhibitor- C gmp phosphodiesterase 5 inhibitor
• PDE5 expressed mainly in sm of corpus cavernosum, retina, lungs, vascular sm
• High dose for pulmonary HTN
• AE- HA, flushing, MI, Sudden cardiac death, temp or perm vision loss
• Do NOT use with other nitrates