Respiratory Flashcards
1
Q
Epinephrine
A
- alpha and beta 1,2 agonist
- Acute bronchospasm, glaucoma, v fib, v tach
2
Q
Codeine
A
- Opioid anti-tussives- decrease reflexive response, acct on cough center in the medulla
3
Q
Hyrocodone
A
- Opioid anti-tussives- decrease reflexive response, acct on cough center in the medulla
4
Q
Dextromethorphan
A
- Opioid anti-tussives- decrease reflexive response, acct on cough center in the medulla
- also non selective SSRI, metabolite is NMDA receptor antagonist
- hallucinogen at a high dose
5
Q
Benzonatate
A
- Chemically related to procaine- anesthetizes stretch receptors in resp tract, reduces cough reflex
- cough suppressant
- BLACK BOX psychiatric changes, accidental OD in kids
- AE- drowsy, N, HA, constipation
6
Q
Guaifenesin
A
- Selective alpha 2 agonist
- loosens/thins mucus, increases production of resp tract fluids
- reduced impulsivity in ADHD
- AE- decrease in BP and HR
7
Q
Diphenhydramine
A
- 1st gen antihistamine- inhibit histammeric signals from vestibular nucleus- vomiting center in the medulla- anticholinergic
- allergic conjuctivitis, urticaria, angioedema, dermatophraphism, motion sickness, sleep, parkinsonism
- selective activity for serotonin syndrome, SSRI induced sexual dysfunction
- possibly effective for- night mares, PTSD, migraine, hyperhidrosis, cyclical vomiting, refractive schixophrenia
- BLACK BOX do not use in GI/GU obstructions, narrow angle glaucoma
- AE- anticholinergic sx
8
Q
Hydraxyzine
A
- 1st gen antihistamine- inhibit histammeric signals from vestibular nucleus- vomiting center in the medulla- anticholinergic
- allergic conjuctivitis, urticaria, angioedema, dermatophraphism, motion sickness, sleep, parkinsonism
- selective activity for serotonin syndrome, SSRI induced sexual dysfunction
- possibly effective for- night mares, PTSD, migraine, hyperhidrosis, cyclical vomiting, refractive schixophrenia
- BLACK BOX do not use in GI/GU obstructions, narrow angle glaucoma
- AE- anticholinergic sx
9
Q
Promethazine
A
- 1st gen antihistamine- inhibit histammeric signals from vestibular nucleus- vomiting center in the medulla- anticholinergic
- allergic conjuctivitis, urticaria, angioedema, dermatophraphism, motion sickness, sleep, parkinsonism
- selective activity for serotonin syndrome, SSRI induced sexual dysfunction
- possibly effective for- night mares, PTSD, migraine, hyperhidrosis, cyclical vomiting, refractive schixophrenia
- BLACK BOX do not use in GI/GU obstructions, narrow angle glaucoma
- AE- anticholinergic sx
10
Q
Loratadine
A
- 2nd gen antihistamine- block histamine release from mast cells
- useful for seasonal allergic rhinitis- inverse agonists- stabalize inactive H1 receptor confirmation
- P450 INHIBITORS
- AE- very little dry mouth or drowsiness
11
Q
Cetirizine
A
- 2nd gen antihistamine- block histamine release from mast cells
- useful for seasonal allergic rhinitis- inverse agonists- stabalize inactive H1 receptor confirmation
- P450 INHIBITORS
- AE- very little dry mouth or drowsiness
12
Q
Fexofenadine
A
- 2nd gen antihistamine- block histamine release from mast cells
- useful for seasonal allergic rhinitis- inverse agonists- stabalize inactive H1 receptor confirmation
- P450 INHIBITORS
- AE- very little dry mouth or drowsiness
13
Q
Epinephrine
A
- Decongestant- acetylcysteine- mucolytic
14
Q
Psuedoephedrine
A
- Mixed acting agonist of adrenergic receptors, potential for abuse to make crystal meth
- adrenergic agonist in nasal passages/ sinuses- vasoconstrict to decrease mucus, fullness
15
Q
Phenylephrine
A
- alpha selective agonist, less effectively absorbed, more frequent dosing needed
- adrenergic agonist in nasal passages/ sinuses- vasoconstrict to decrease mucus, fullness
- BLACK BOX exacerbation of angina, HF, pulm HTN, bradycardia, autonomic sydfxn, peripheral ischemia, KD tox
