Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology Exam > Immune Suppression > Flashcards

Immune Suppression Flashcards

1
Q

Raloxifene

A
  • Chemo- SERM
  • Antagonist in uterine and breast tissue, partial bone agonist
  • breask ca
  • pregnancy X
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Tamoxifen

A
  • Chemo- SERM
  • competes with estradiol for estrogen receptor proteins
  • metastatic breast ca
  • pregnancy D
  • BLACK BOX uterine malignancy, sroke, PE
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Leuprolide

A
  • Chemo- LH-RH agonist/ GnRH analogue
  • initial stimulatory continuous dosing
  • supress ovary/testes steroidogenesis
  • prostate ca, precosious puberty, endometriosis, fibroids
  • Pregnancy X
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Anastrozole

A
  • Chemo- aromatase inhibitor
  • irreversible inhibitio nof androgen to estrogen
  • postmenopausal
  • E receptor pos breast ca, BPH, prostate ca
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Bicalutamide

A
  • Chemo- testosterone agonist
  • metestatic prostate ca
  • CI in women
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Doxorubicin

A
  • Chemo- anthracycline
  • one of the most useful ca drugs, used in a variety of dz
  • preg D
  • BLACK BOX myolosupression, cardiotoxicity, liver impairment
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Methotrexate

A
  • Chemo- anti-metabolite/ anti-folate
  • used in many ca, ra, psoriasis, organ transplant
  • pregnancy X
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Vinbiastine

A
  • Chemo- anti-microtubule/ mitotic disruptor
  • IV only- other routes fatal
  • derived from periwinkle
  • lymphoma, head/neck, hormone ca
  • pregnancy D
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Paclitaxel

A
  • Chemo- anti-microtubule/ mitotic disruptor
  • From pacific yew similar to vinbiastine
  • pregnancy D
  • BLACK BOX neutropenia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

5-flourouracil

A
  • Chemo- pyrimidine analogue
  • narrow therapeutic margin
  • pregnancy D
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Trastuzumab

A
  • Chemo- HER2 inhibitor
  • breast ca, metastatic breast ca, gastric ca
  • pregnancy D
  • BLACK BOX serious heart problems, lots of fatality, fetal harm
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Cyclophosphamide

A
  • Chemo- alkylating agent- interfere with synthesis of all the transcription things
  • advanced mycosis fungoides, lymphomas
  • pregnancy D
  • BLACK BOX renal tox, myelosuppression, ototoxicity, alaphylactic like reaction.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Cisplatin

A
  • Chemo- alkylating agent- interfere with synthesis of all the transcription things
  • metastatic t/ovarian and advanced bladder ca
  • pregnancy D
  • BLACK BOX renal tox, myelosuppression, ototoxicity, alaphylactic like reaction.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Cyclosporine

A
  • Immune suppression
  • transplant, severe RA, psoriasis, also eye formula for dry eyes
  • MANY interactions and toxicities
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Tacrolimus

A
  • Immune suppression
  • transplant, severe RA, severe atopic derm
  • MANY interactions and toxicities
  • BLACK BOX malignancy and serious infection
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Adalimumab

A
  • Immune suppression
  • TNF inhibitor/ MAB
  • RA, psoriasis/arthritis, AS, IBD, UC
  • pregnancy B
17
Q

Infliximab

A
  • Immune suppression
  • TNF inhibitor/ MAB
  • RA, psoriasis/arthritis, AS, IBD, UC
  • pregnancy B
18
Q

Etanercept

A
  • Immune suppression
  • cytokine inhibitor- inactivates TNF
  • RA, psoriatic/plaque psoriasis, AS
  • BLACK BOX serious fatal infection
19
Q

Methotrexate

A
  • Immune suppression
  • DMARD
  • RA, psoriasis, graft vs host
  • pregnancy X
20
Q

Sulfasalazine

A
  • Immune suppression
  • DMARD
  • RA, UC, Crohn’s, AS, psoriatic
  • pregnancy B
21
Q

Hydroxychloroquine

A
  • Immune suppression
  • DMARD
  • RA, SLE, antimalarial
  • rare eye toxicity
  • pregnancy no cat
22
Q

Penicillamine

A
  • Immune suppression
  • DMARD
  • RA, wilsons dz
  • pregnancy D
23
Q

Tofacitinib

A
  • Immune suppression
  • DMARD
  • moderate to severe RA
  • pregnancy X
  • BLACK BOX serious fatal infection, future cancer
24
Q

Thalidomide

A
  • Immune modulator- anti angiogenic
  • leprosy
  • pregancy X
25
Q

Atezolizumab

A
  • Chemo
  • inhibition of T-cell supression
  • restor antitumor T cell function
  • many ca
  • Likely causes fetal harm
26
Q

Ipilimumab

A
  • Chemo
  • inhibition of T-cell supression
  • restor antitumor T cell function
  • many ca
  • Likely causes fetal harm
27
Q

Pembrolizumab

A
  • Chemo
  • inhibition of T-cell supression
  • restor antitumor T cell function
  • many ca
  • Likely causes fetal harm

Pharmacology Exam (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions