Urinary Bladder Flashcards
In a study of 21 dogs using IMRT/IGRT for urinary bladder cancer in the dog, what was the median time to first event?
11 mos
In a study of 10 dogs using PRT for urinary bladder cancer, what was the median TTP?
What was the difference between RT + mitoxantrone + piroxicam versus mitoxantrone + piroxicam?
3 mos
No significant difference
In general, what percentage of dogs with urinary bladder cancer have mets: a) at dx? b) at death?
15%
50%
List 7 risk factors for urinary bladder cancer:
- female (1.9-1.0)
- obesity
- flea products - older generation
- herbicides alone (OR 3.6)
- Herbicides + insecicides (7.2)
- breed (Scottie 18)
- neuter dog increased risk
Urinary bladder tumors are positive for what stain?
UP III (uroplakin)
What is the general Sn and Sp for urine Ag tests for TCC (i.e. high vs low)?
Highly Sn
Low Sp
Why are multifocal TCCs common in the bladder?
Due to field-effect secondary to carcinogens in urine
In regards to prostate tumors in dogs, is ACA more common in intact or castrated males?
Castrated
Canine prostatic tumors arise from what tissue?
Are they androgen dependent or independent
Urothelial or ductular orgin, not acinar.
Independent
What is the overall metastatic rate of canine prostatic tumors, and to what tissues?
80% metastatic rate - lung, LN
22-42% develop bone mets: osteoblastic/osteoproliferative - related to PTHrp/TGF-ß
Do canine prostate tumors express Cox-2?
Yes - 75-88% do.
Survival advantage if treated w piroxicam or carprofen
Mineralization of the canine prostate can occur with what condition(s)?
neoplasia, BPH, prostatitis, cysts
CASTRATED dogs with prostate mineralization - Sn & Sp?
likely neoplasia
84% Sn
100% Sp
INTACT dogs w prostate mineralization - Sn & Sp?
67% Sn
77% Sp
(NPV 96% - unlikely to have neoplasia of no minerlization)
