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RO General Section > Brain > Flashcards

Brain Flashcards

0
Q

In a study of 24 dogs treated for pituitary tumors, what was the significance of relative tumor size?

A

Increase relative tumor size is associated with poorer prognosis.
Dogs w > 12% RTS had 4X increase risk for progression.

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1
Q

In a study of 46 dogs with pituitary tumors, the MST for dogs treated with DRT was how long?

A

1405 days (47 mos)

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2
Q

In a study of 24 dogs treated for pituitary tumors, dogs with inactive tumors had…

A

6X increased risk of progression vs. dogs w PDH

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3
Q

In a study of 24 dogs treated for pituitary tumors, the effect of severity of neurologic signs was that…

A

Severity of neurologic signs affected survival.

PFS 21 months for mild/moderate verses 13 months for severe neuro signs

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4
Q

In general, regarding canine pituitary tumors, the range of:

  1. resolution of signs of Cushings?
  2. resolution of neurological signs?
A
  1. 32-36%

2. 36-100%

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5
Q

In a study of 24 dogs treated for pituitary tumors, did RT improve survival of dogs with severe neuro signs?

A

No

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6
Q

In a study of 24 dogs treated for pituitary tumors, was tumor volume a prognostic factor?

A

No (RTS is, but not absolute size)

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7
Q

In a study of 24 dogs treated for pituitary tumors, did tumor size predict severity of neuro signs

A

No

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8
Q

In a study of 46 dogs treated w DRT for pituitary tumors, what 2 indices were found to be associated with decreased MST?

A

pituitary: brain height ratio > 25%, or

pituitary :brain area ratio >5%

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9
Q

In a study of 46 dogs treated w DRT for pituitary tumors, what was the difference in survival for dogs w or w/o neuro signs?

A

In the RT group, there was NO difference in survival

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10
Q

Regarding diagnostic tests for dogs with PDH, what are the relative Sn/Sp of the following tests:

  1. UCCR
  2. ACTH stim
  3. LDDST
A
  1. high Sn, low Sp
  2. lower Sn, higher Sp
  3. highly Sn
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11
Q

What endogenous ACTH levels are seen in dogs with:
ADH?
PDH?

A

Low

High

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12
Q

In a study of 20 dogs treated with sx + RT for intracranial meningiomas, what marker was found to be related to recurrence, and what were the 2 yr PFS for low vs. high levels of the marker?

A

PCNA
If PCNA> 24%, 9X more likely to recur
Low PCNA 91%
High PCNA 42%

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13
Q

In a study of 46 dogs treated with RT for intracranial neoplasms, was there a significant difference in survival based on:
severity of neuro signs?
tumor type?

A

No
No
(these findings are controversial)

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14
Q

Name 4 negative prognostic factors for intracranial neoplasms.

A
  1. Tumors other than meningioma
  2. Rapid new progression
  3. Multiple masses
  4. Incr WBC in CSF
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15
Q

List 3 positive prognostic factors for intracranial neoplasms in the dog.

A
  1. Solitary vs. multiple lesions
  2. Limited neuro signs
  3. Forebrain vs. caudal brain meningiomas
16
Q

In choroid plexus tumors, local spread can occur and distant mets are present in what % of dogs?
What % have spinal cord mets?
What CSF change is seen?

A

50%
19%
increased CSF protein

17
Q

In dogs with intracranial neoplasms, what % have a 2nd tumor unrelated to their brain tumor?

A

23-25%

18
Q

In dogs treated for meningioma with RT + surgery, what is the impact of VEGF expression?

A

If < 75% staining, MST = 25 mos

If > 75% staining, MST = 15 mos

19
Q

What percentage of meningiomas have lung mets?

A

15%

20
Q

What CSF tap changes are seen with intracranial neoplasms?

A

increase protein
normal to increased WBC
most common abnormality is mixed cell pleocytosis
neutrophilic pleocytosis only seen in meningiomas

21
Q

In a study of 14 cats with acromegaly treated with radiation therapy, what % had resolution of their diabetes?

A

43%

22
Q

In a study of 14 cats with acromegaly treated with radiation therapy, What was the relationship between IGF-1 concentration and glycemic control?

A

IGF-1 levels did NOT reflect clinical improvement in glycemic control

RO General Section (17 decks)

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