Brain Flashcards
In a study of 24 dogs treated for pituitary tumors, what was the significance of relative tumor size?
Increase relative tumor size is associated with poorer prognosis.
Dogs w > 12% RTS had 4X increase risk for progression.
In a study of 46 dogs with pituitary tumors, the MST for dogs treated with DRT was how long?
1405 days (47 mos)
In a study of 24 dogs treated for pituitary tumors, dogs with inactive tumors had…
6X increased risk of progression vs. dogs w PDH
In a study of 24 dogs treated for pituitary tumors, the effect of severity of neurologic signs was that…
Severity of neurologic signs affected survival.
PFS 21 months for mild/moderate verses 13 months for severe neuro signs
In general, regarding canine pituitary tumors, the range of:
- resolution of signs of Cushings?
- resolution of neurological signs?
- 32-36%
2. 36-100%
In a study of 24 dogs treated for pituitary tumors, did RT improve survival of dogs with severe neuro signs?
No
In a study of 24 dogs treated for pituitary tumors, was tumor volume a prognostic factor?
No (RTS is, but not absolute size)
In a study of 24 dogs treated for pituitary tumors, did tumor size predict severity of neuro signs
No
In a study of 46 dogs treated w DRT for pituitary tumors, what 2 indices were found to be associated with decreased MST?
pituitary: brain height ratio > 25%, or
pituitary :brain area ratio >5%
In a study of 46 dogs treated w DRT for pituitary tumors, what was the difference in survival for dogs w or w/o neuro signs?
In the RT group, there was NO difference in survival
Regarding diagnostic tests for dogs with PDH, what are the relative Sn/Sp of the following tests:
- UCCR
- ACTH stim
- LDDST
- high Sn, low Sp
- lower Sn, higher Sp
- highly Sn
What endogenous ACTH levels are seen in dogs with:
ADH?
PDH?
Low
High
In a study of 20 dogs treated with sx + RT for intracranial meningiomas, what marker was found to be related to recurrence, and what were the 2 yr PFS for low vs. high levels of the marker?
PCNA
If PCNA> 24%, 9X more likely to recur
Low PCNA 91%
High PCNA 42%
In a study of 46 dogs treated with RT for intracranial neoplasms, was there a significant difference in survival based on:
severity of neuro signs?
tumor type?
No
No
(these findings are controversial)
Name 4 negative prognostic factors for intracranial neoplasms.
- Tumors other than meningioma
- Rapid new progression
- Multiple masses
- Incr WBC in CSF
List 3 positive prognostic factors for intracranial neoplasms in the dog.
- Solitary vs. multiple lesions
- Limited neuro signs
- Forebrain vs. caudal brain meningiomas
In choroid plexus tumors, local spread can occur and distant mets are present in what % of dogs?
What % have spinal cord mets?
What CSF change is seen?
50%
19%
increased CSF protein
In dogs with intracranial neoplasms, what % have a 2nd tumor unrelated to their brain tumor?
23-25%
In dogs treated for meningioma with RT + surgery, what is the impact of VEGF expression?
If < 75% staining, MST = 25 mos
If > 75% staining, MST = 15 mos
What percentage of meningiomas have lung mets?
15%
What CSF tap changes are seen with intracranial neoplasms?
increase protein
normal to increased WBC
most common abnormality is mixed cell pleocytosis
neutrophilic pleocytosis only seen in meningiomas
In a study of 14 cats with acromegaly treated with radiation therapy, what % had resolution of their diabetes?
43%
In a study of 14 cats with acromegaly treated with radiation therapy, What was the relationship between IGF-1 concentration and glycemic control?
IGF-1 levels did NOT reflect clinical improvement in glycemic control
