Anal Sac Flashcards
In a study of 15 dogs with anal sac ACA treated w post-op RT & mitoxantrone, what was the effect of lymph node mets on outcome?
Despite a EFS difference of 29 vs 9 mos, this was NOT statistically significant. EFS = event-free survival
In a study of 15 dogs with anal sac ACA treated w post-op RT & mitoxantrone:
What percentage had hypercalcemia?
What % had regional LN mets removed?
MST?
27%
47%
32 mos (mDFI = 10 mos)
In a study of 113 dogs using various therapies for anal sac CA:
- If the tumor volume was > ___, MST was ___ vs ___ mos.
- ___% had hypercalcemia, MST was ___ vs ___mos.
- If tumor > 10 cm3, decr MST: 10 vs 19 mos
2. 27%, decr MST: 8 vs 19 mos
In a study of 113 dogs using various therapies for anal sac CA:
- ____% had abdominal LN increase.
- What effect did iliac LN increase have on outcome?
- ____% had pulmonary mets.
- MST w pulmonary mets ___%, MST w/o ____%.
- 47
- No. Iliac LN incr. did NOT affect outcome
- 7
- 7 vs 18 mos
Generally, concerning anal sac ACA:
What is the met rate to sublumbar LN?
What % of dogs have HHM?
50% at diagnosis
27%…mediated by PTHrp
List 7 negative prognostic factors regarding dogs with anal sac ACA.
- large primary tumor size
- mets - LN & distant
- Advanced clinical stage
- No tx
- Tx w chemo alone (MST 7 mos)
- Not removing metastatic LNs - removing them improved survival
- Hypercalcemia - decreases survival…debatable
Regarding hypercalcemia and dogs with anal sac ACA:
Will it resolve after tumor removal?
Recurrence signals what?
Yes
Recurrence signals mets or local recurrence
In dogs with anal sac ACA, E-cadherin expression was associated with what?
Increased MST and decreased mets
In dogs with anal sac ACA, E-cadherin expression in >____% of cells (increases/decreases) MST from _____ to ____mos.
75…increases……15….39
If > 75%, longer MST: 39 vs 15 mos
