PDT, Hyperthermia

Question 0

In a study of 64 dogs treated for STS w RT alone vs RT + hyperthermia, what was the effect on local control, late effects, and metastatic rate?

Answer 0

increase duration of local control

no increase in late effects or metastatic rate

Question 1

In a study of 64 dogs treated for STS w RT alone vs RT + hyperthermia did hyperthermia produce a therapeutic gain?

Answer 1

yes

Question 2

In a study of 64 dogs with STS treated w RT + local hyperthermia vs RT+local+whole body hyperthermia:

1. Difference in local control?
2. Time to metastasis difference?
3. Any difference in complications between groups?

Answer 2

1. no difference
2. time to mets shorter in LH/WBH group
3. complications greater for LH/WBH group
   NO rationale for further study of LH/WBH in STS

Question 3

In a study of 122 dogs treated for STS w high vs. low thermal dose of local hyperthermia, what results were found?

Answer 3

Thermal dose is directly related to local control duration

Question 4

In 38 dogs treated for oral carcinoma with RT alone vs RT + local hypethermia:
RT alone: 40 Gy - ___% control; 45 Gy - ___% control
RT + local hyperthermia results?

Answer 4

57….75

100% control at both 40&45 Gy

Question 5

In 45 dogs w brain masses treated w RT alone or RT+WBH:

1. Difference in toxicity between groups?
2. Difference in survival between groups?

Answer 5

1. WBH assoc w increased toxicity

2. No diff in survival

Question 6

Regarding intranasal brachytherapy, what tissue is does limiting?

Answer 6

bone

Question 7

In 13 cats treated for superficial SCC using PDT and 5-ALA:
___% CR
___% local recurrence at 5 mos
once in cells, 5-ALA is converted to ______, a light sensitive chemical

Answer 7

85
64
protoporphyrin IX

Question 8

In 18 cats treated for superficial SCC w PDT using a liposomal photosensitizer (m-THPC):
____% CR
1 yr PFI: ____%
___% local recurrence at median time of 6 mos

Answer 8

100
75
20

Question 9

In 55 cats treated with PDT using 5-ALA for nasal planum SCC:
___% CR
___% local recurrence at median time of 5 mos

Answer 9

85

51

Question 10

Name 3 things needed for PDT.

Answer 10

1. Oxygen
2. photosensitizer
3. light of appropriate wavelength

Question 11

How does PDT kill cells?

Answer 11

Indirectly by singlet oxygen (free radical)

Question 12

Does PDT work in hypoxic cells

Answer 12

No