Nasal

Question 0

Epistaxis effect on canine nasal tumors treated w NSAIDs alone?

Answer 0

Decreased survival

3 mos vs. 7 mos

Question 1

MST for nasal canine nasal tumors w NSAIDs alone?

Answer 1

3.2 mos

Question 2

In a study of orthovoltage and MV treatment of canine nasal tumors, does Sx + RT improve survival time over RT alone?

Answer 2

yes

Question 3

In a study of canine nasal tumors, was there a difference between nasal tumors treated w RT alone vs RT and orthovoltage or MV?

Answer 3

Yes, significant improved MST for RT + Sx over RT alone for orthovoltage, but NOT w MV.

Question 4

In a study comparing Sx + RT vs RT alone w orthovoltage & MV for canine nasal tumors, how did tumors of different tissue types respond compared to each other?

Answer 4

Dogs with SCC/undifferentiated carcinomas had decreased survival vs. dogs with ACA or sarcomas (disputed by other papers)

Question 5

In a study comparing Sx + RT vs RT alone w orthovoltage & MV for canine nasal tumors, name 2 factors post-RT that decreased MST

Answer 5

recurrence of disease

recurrence of epistaxsis

Question 6

In dogs treated with Sx + RT for nasal tumors, what was the impact of resolution of clinical signs post-RT?

Answer 6

they lived significantly longer

16 vs 4 mos

Question 7

In a 2005 study of Co-60 RT followed by exenteration, what was MST for RT only and for RT + Sx?

Answer 7

20 mos

48 mos

Question 8

For dogs with nasal tumors treated by DRT, what was
MST?
median DFI?

Answer 8

6-14 mos

6-10 mos

Question 9

Regarding dogs with nasal tumors treated with DRT, list 3 negative prognostic factors

Answer 9

dogs > 10 yrs
LN mets
higher stage

Question 10

In a paper regarding a modified staging scheme for canine nasal tumors, what types of tumors were associated with decreased DFS, and what was the DFS for that group?

Answer 10

anaplastic/undifferentiated/SCC group was less than sarcoma group
4 mos

Question 11

In a paper regarding a modified staging scheme for canine nasal tumors, which stages had significantly decreased DFS and MST?

Answer 11

Adams Stage IV and modified Adams Stage IV

Question 12

In a paper regarding a modified staging scheme for canine nasal tumors, the shortest DFS & MST was noted in what dogs? What were the DFS & MST?

Answer 12

dogs w cribriform involvement
DFS 4 mos
MST 7 mos

Question 13

In an accelerated protocol (4.2 Gy x 10) for canine nasal tumors, what was the difference in DFS & MST for Stage I/II vs Stage III/IV?

Answer 13

stage I/II had increased DFS/MST over stage III/IV dogs

25 vs 10 mos

Question 14

In a study of dogs with nasal tumors w metastasis to LN or lung, what was the MST?

Answer 14

4 mos (vs 13 mos)

Question 15

In a follow-up study of dogs with nasal tumors comparing cisplatin and RT vs. RT alone,
what was the MST?
did chemo have an effect on survival or toxicity?

Answer 15

16 mos

no

Question 16

MST and median DFI for canine nasal tumors tx w PRT?

Answer 16

5-10 mos

4-10 mos

Question 17

In one study of PRT for canine nasal tumors, compare median PFI and MST for Adams stage I/II vs. Adams stage III/IV.
What was the overall CR range?

Answer 17

Stages I/II longer than III/IV
PFIs: 21 vs 8 mos
MSTs: 18 vs 9 mos
66-100%

Question 18

In a study of 48 dogs w nasal tumors treated with various coarse fx protocols:
Dogs w clinical signs < ___ days prior to dx were ___x more likely to relapse.

Answer 18

90……4.1

Question 19

In a study of 48 dogs w nasal tumors treated with various coarse fx protocols:
dogs that did not have CR of clinical signs were ___x more likely to die vs. dogs w CR (MST ___ mos vs. ___mos)

Answer 19

3

1…8

Question 20

In a study of 48 dogs w nasal tumors treated with various coarse fx protocols:
___% of dogs with initial response were treated with a 2nd course -> ___% had CR after the 2nd course

Answer 20

23

82

Question 21

In a 2013 study of dogs treated for nasal tumors w PRT:
What was the MST?
___% had sx before RT
Was there a difference between RT alone vs RT + Sx?

Answer 21

17 mos
18
no

Question 22

What % of nasal carcinomas are COX-2 positive?

Does COX-2 correlate w tumor type or MST?

Answer 22

90

no

Question 23

In a study of 9 dogs with nasal tumors re-irradiated for their neoplasm:
MST?
___% of dogs had late effects after 2nd tx
___% had severe late effects, which was _______

Answer 23

100
22…..acute blindness
(78% of late effects were not life-threatening - KCS, alopecia, etc.)

Question 24

In general, what is the metastatic rate of canine nasal tumors:
at dx?
at death?

Answer 24

10-20%

40-50%

Question 25

What is the average duration of clinical signs prior to presentation for canine nasal tumors?

Answer 25

2-3 mos

Question 26

What is the range of recurrence rates for canine nasal tumors in general?

Answer 26

65-100%
sx MST: 3-6 mos
DRT MST: 8-20 mos

Question 27

Do CT-based computer plans improve survival w canine nasal tumors?

Answer 27

No

Question 28

What is the recurrence rate for canine nasal tumors treated with RT?

Answer 28

60%

Question 29

In one study using a boost techniques for canine nasal tumors, the total dose was boosted to 57 Gy without increasing overall tx time. This resulted in…

Answer 29

severe acute effects and 1/3 of patients dying from radiation-induced death.

Question 30

Regarding LSA of the feline nasal cavity:
MST??
CR for DRT??
What is the difference between RT alone vs RT+chemo?
What % had LSA dx at distant sites?

Answer 30

16-31 mos
80-94%
None
18-20%

Question 31

In a study of PRT & DRT for nasal lymphoma in the cat, name two factors that decrease MST. What are the MSTs?

Answer 31

1. Anemia at time of presentation - 3 mos (vs 9)

2. Anorexia at time of presentation - 4 mos (vs11)

Question 32

In a study of PRT & DRT for nasal lymphoma in the cat, name two factors that increase MST.

Answer 32

1. Addition of RT to any protocol (6 mos v 4)

2. RT doses > 32 Gy (13 mos v 6)

Question 33

In a study of PRT & DRT for nasal lymphoma in the cat, what was the difference between PRT and DRT? Did cats that achieve CR live longer?

Answer 33

None

Yes (18 mos v 4)

Question 34

What is the most common nasal tumor in the cat?

What is the relative % of types?

Answer 34

LSA
71% B cell
29% T cell