Nasal Flashcards
Epistaxis effect on canine nasal tumors treated w NSAIDs alone?
Decreased survival
3 mos vs. 7 mos
MST for nasal canine nasal tumors w NSAIDs alone?
3.2 mos
In a study of orthovoltage and MV treatment of canine nasal tumors, does Sx + RT improve survival time over RT alone?
yes
In a study of canine nasal tumors, was there a difference between nasal tumors treated w RT alone vs RT and orthovoltage or MV?
Yes, significant improved MST for RT + Sx over RT alone for orthovoltage, but NOT w MV.
In a study comparing Sx + RT vs RT alone w orthovoltage & MV for canine nasal tumors, how did tumors of different tissue types respond compared to each other?
Dogs with SCC/undifferentiated carcinomas had decreased survival vs. dogs with ACA or sarcomas (disputed by other papers)
In a study comparing Sx + RT vs RT alone w orthovoltage & MV for canine nasal tumors, name 2 factors post-RT that decreased MST
recurrence of disease
recurrence of epistaxsis
In dogs treated with Sx + RT for nasal tumors, what was the impact of resolution of clinical signs post-RT?
they lived significantly longer
16 vs 4 mos
In a 2005 study of Co-60 RT followed by exenteration, what was MST for RT only and for RT + Sx?
20 mos
48 mos
For dogs with nasal tumors treated by DRT, what was
MST?
median DFI?
6-14 mos
6-10 mos
Regarding dogs with nasal tumors treated with DRT, list 3 negative prognostic factors
dogs > 10 yrs
LN mets
higher stage
In a paper regarding a modified staging scheme for canine nasal tumors, what types of tumors were associated with decreased DFS, and what was the DFS for that group?
anaplastic/undifferentiated/SCC group was less than sarcoma group
4 mos
In a paper regarding a modified staging scheme for canine nasal tumors, which stages had significantly decreased DFS and MST?
Adams Stage IV and modified Adams Stage IV
In a paper regarding a modified staging scheme for canine nasal tumors, the shortest DFS & MST was noted in what dogs? What were the DFS & MST?
dogs w cribriform involvement
DFS 4 mos
MST 7 mos
In an accelerated protocol (4.2 Gy x 10) for canine nasal tumors, what was the difference in DFS & MST for Stage I/II vs Stage III/IV?
stage I/II had increased DFS/MST over stage III/IV dogs
25 vs 10 mos
In a study of dogs with nasal tumors w metastasis to LN or lung, what was the MST?
4 mos (vs 13 mos)
In a follow-up study of dogs with nasal tumors comparing cisplatin and RT vs. RT alone,
what was the MST?
did chemo have an effect on survival or toxicity?
16 mos
no
MST and median DFI for canine nasal tumors tx w PRT?
5-10 mos
4-10 mos
In one study of PRT for canine nasal tumors, compare median PFI and MST for Adams stage I/II vs. Adams stage III/IV.
What was the overall CR range?
Stages I/II longer than III/IV
PFIs: 21 vs 8 mos
MSTs: 18 vs 9 mos
66-100%
In a study of 48 dogs w nasal tumors treated with various coarse fx protocols:
Dogs w clinical signs < ___ days prior to dx were ___x more likely to relapse.
90……4.1
In a study of 48 dogs w nasal tumors treated with various coarse fx protocols:
dogs that did not have CR of clinical signs were ___x more likely to die vs. dogs w CR (MST ___ mos vs. ___mos)
3
1…8
In a study of 48 dogs w nasal tumors treated with various coarse fx protocols:
___% of dogs with initial response were treated with a 2nd course -> ___% had CR after the 2nd course
23
82
In a 2013 study of dogs treated for nasal tumors w PRT:
What was the MST?
___% had sx before RT
Was there a difference between RT alone vs RT + Sx?
17 mos
18
no
What % of nasal carcinomas are COX-2 positive?
Does COX-2 correlate w tumor type or MST?
90
no
In a study of 9 dogs with nasal tumors re-irradiated for their neoplasm:
MST?
___% of dogs had late effects after 2nd tx
___% had severe late effects, which was _______
100
22…..acute blindness
(78% of late effects were not life-threatening - KCS, alopecia, etc.)
In general, what is the metastatic rate of canine nasal tumors:
at dx?
at death?
10-20%
40-50%
What is the average duration of clinical signs prior to presentation for canine nasal tumors?
2-3 mos
What is the range of recurrence rates for canine nasal tumors in general?
65-100%
sx MST: 3-6 mos
DRT MST: 8-20 mos
Do CT-based computer plans improve survival w canine nasal tumors?
No
What is the recurrence rate for canine nasal tumors treated with RT?
60%
In one study using a boost techniques for canine nasal tumors, the total dose was boosted to 57 Gy without increasing overall tx time. This resulted in…
severe acute effects and 1/3 of patients dying from radiation-induced death.
Regarding LSA of the feline nasal cavity:
MST??
CR for DRT??
What is the difference between RT alone vs RT+chemo?
What % had LSA dx at distant sites?
16-31 mos
80-94%
None
18-20%
In a study of PRT & DRT for nasal lymphoma in the cat, name two factors that decrease MST. What are the MSTs?
- Anemia at time of presentation - 3 mos (vs 9)
2. Anorexia at time of presentation - 4 mos (vs11)
In a study of PRT & DRT for nasal lymphoma in the cat, name two factors that increase MST.
- Addition of RT to any protocol (6 mos v 4)
2. RT doses > 32 Gy (13 mos v 6)
In a study of PRT & DRT for nasal lymphoma in the cat, what was the difference between PRT and DRT? Did cats that achieve CR live longer?
None
Yes (18 mos v 4)
What is the most common nasal tumor in the cat?
What is the relative % of types?
LSA
71% B cell
29% T cell
