Oral tumors

Question 0

In a study of 28 dogs treated w Sx + RT for oral FSA:

mPFS?

Answer 0

26 mos

Question 1

In a study of 17 dogs treated with orthovoltage for oral FSA:
MST??
mDFI??

Answer 1

7 mos

4 mos

Question 2

In a study of 28 dogs treated w Sx + RT for oral FSA:

Dogs w T2 (___x) and w T3 (___x) higher risk of tumor progression than T1.

Answer 2

3 and 5

2.9 and 4.9

Question 3

In a study of 28 dogs treated w Sx + RT for oral FSA:

Dogs w T2 (___x) and those w T3 (___x) higher risk of local recurrence vs. T1

Answer 3

3 and 6

2.8 and 6.4

Question 4

In a study of 28 dogs treated w Sx + RT for oral FSA:
compare MV to orthovoltage
what influenced time to failure?

Answer 4

MV better than RT for oral tumors

T stage

Question 5

In a study of 31 dogs w oral FSA treated w RT for microscopic dx, what was the difference in MST & PFI for DRT vs PRT?

Answer 5

There was NO significant difference:
11 mos DRT (ORR 70%)
10 mos PRT (ORR 63%)

Question 6

In a study of 25 dogs w hi-low FSA:
MST for Sx + RT?
Most common breed & %?
%bone lysis?
% mets?

Answer 6

18 mos
Golden retr, 52%
72%
20%

Question 7

Generally, dogs w oral FSA have:
____% overall mets?
____% LN mets?
____% pulmonary mets?

Answer 7

less than 30%
19-22%
27%

Question 8

In general, the survival with sx alone for oral FSA with mandibulectomy vs. maxillectomy results in MST of:

Answer 8

11 mos mandible

12 mos maxilla

Question 9

In a study of 29 dogs with oral FSA treated with Sx vs. Sx + RT:
MST & mPFI?
Difference in MST for two groups?
Effect of mets on MST?

Answer 9

25 mos: >22 mos
no difference
shorter at 13 mos

Question 10

In dogs treated with surgery for oral OSA:

MST & local recurrence rate for mandibulectomy and maxillectomy?

Answer 10

mandible: 14-18 mos, 15%
maxilla: 5-10 mos, 83-100%

Question 11

In dogs treated for oral OSA w surgery alone:
Effect of margins on MST?
Effect of chemo or RT for incompletely resected tumors?

Answer 11

Complete margins are key: > 50 mos complete; 7 mos incomplete
Chemo or RT didn’t improve outcome

Question 12

In general, the MST for epulides is:

Answer 12

48 mos

Question 13

In a study of 57 dogs with epulides, dogs below what age lived significantly longer? DFI?

Answer 13

Dogs <8 yrs (77 vs 37 mos)

DFI = 40 mos

Question 14

In a study of 47 dogs w epulides:
3 yr PFS = ____%
Dogs w stage T3 tumors had ____x increased risk of recurrence vs stage T1 tumors.
Effect of stage on PFS?

Answer 14

80%
~8 (7.9)
T3s had sig decreased PFS vs T1/T2s
(4%RIT)

Question 15

In epulides, the most common location for:
fibromatous?
acanthomatous?

Answer 15

rostral maxilla

rostral mandible

Question 16

Range of recurrence rate for RT alone of epulides?

Answer 16

8-18%

Question 17

What chemotherapy has been used intralesionally for epulides and what is the CR and mDFI?

Answer 17

Bleomycin, 100%, >12 mos

Question 18

Concerning oral lymphoma in the dog treated w RT± chemo:
MST?
% that developed systemic disease?
Difference with LN involvement?
Effect of CR?

Answer 18

25 mos
71%
Dogs w/o LN involvement >67 mos vs 10
Dogs w CR lived longer

Question 19

Regarding oral tumors in general following RT, tumor recurrence is a function of size:
T2 tumors are ___x more likely to recur than T1
T3 tumors are ___x more likely to recur than T1

Answer 19

3

6-8

Question 20

Regarding oral tumors in general following RT, tumor size is often associated with survival. The 3 yr PFS for T1, T2, and T3 are:

Answer 20

55%, 32%, 20%