LSA, Half Body

Question 0

In a study of 13 dogs of HBI for lymphoma comparing 8 Gy x 2 vs 6 Gy x 2, given 2 wks apart, there was increased skin dose to one half of the body. Which half and why?

Answer 0

Cranial half

Due to lung transmission

Question 1

In a study of 94 dogs using 8 Gy repeated in 3 wks HBI for lymphoma, how did duration of remission compare to using chemo alone?
What negative prognostic factor was found?

Answer 1

No improvement over chemo alone (med duration of 1st remission 10 mos)
Anemia

Question 2

In a study of 13 dogs of HBI for lymphoma comparing 8 Gy x 2 vs 6 Gy x 2, given 2 wks apart, what was the difference between CR and no CR at time of RT?

Answer 2

There was none.

Median duration of remission = 37 mos; hemotologic tox was greater in the 8 Gy dogs; LDR [8-14 cGy/min]

Question 3

In a follow-up study of 38 dogs of HBI using 6 Gy x 2, two weeks apart, what was the % CR at time of RT?

Answer 3

87%

MST was 23 mos for this study

Question 4

In a follow-up study of 38 dogs of HBI using 6 Gy x 2, two weeks apart, what two factors were prognostic for remission duration?

Answer 4

Substage: substage A did better
Phenotype: B-cell better

Question 5

In a HBI study of 29 dogs using 8 Gy x 2 given 4 weeks apart vs. 6 Gy x 2 given 4 weeks apart, what was the CR at time of RT?

Answer 5

83%

Question 6

In a HBI study of 29 dogs using 8 Gy x 2 given 4 weeks apart vs. 6 Gy x 2 given 4 weeks apart, the MST was lower than in other studies. What was the MST and why was it lower?

Answer 6

10 mos

Because it was used as a rescue protocol in some dogs

Question 7

Dogs irradiated as part of HBI protocols have what times increased relative risk of cancer vs. control dogs?

Answer 7

Five times

Question 8

In a study of bone marrow transplant in 24 dogs using myeloablation with high dose Cytoxan & TBI, name 3 adverse reactions encountered and the % of each.

Answer 8

Pulmonary fibrosis 4%
GI toxicity 96%
RT-related mortality 12%
(MST was 15 mos)

Question 9

In a study of 8 cats with GI lymphoma treated with 1.5 Gy x 10 to the abdomen, what was the CR % for those with disease confined to the abdomen?

Answer 9

100% (all)

lymphoblastic LSA

Question 10

In a study of 8 cats with GI lymphoma treated with 1.5 Gy x 10 to the abdomen:
What % had GI toxicity?
What % relapsed?

Answer 10

62%
25%
(median duration of remission > 9 mos [NR])

Question 11

In a study of 8 cats with GI lymphoma treated with 1.5 Gy x 10 to the abdomen, how did patients compare to standard therapies?

Answer 11

comparable or superior to standard tx

Question 12

In 2 studies of 4 Gy x 2 as rescue protocols for LSA confined to the abdomen in cats, name two negative px factors.

Answer 12

Anemia

Cats weighing < 3.4 kg had decreased MST