Upper GIT Structure & Function Flashcards
why do you need to chew
Prolong taste experience
prevents against respiratory failure
is chewing under voluntary or involuntary control
voluntary
Somatic nerves ⇒ skeletal muscles of mouth/jaw
what is the voluntary control of chewing
Somatic nerves ⇒ skeletal muscles of mouth/jaw
what makes up the chewing reflex
Contraction of jaw muscles
what does contraction of jaw muscles result in
pressure of food against gums, hard palate and tongue ⇒ mechanoreceptors
inhibition of jaw muscles ⇒ reduced pressure ⇒ contraction
what makes up saliva
water
mucins
alpha amylase
electrolytes
lysozyme
water
99% of secreted fluid. Softens, moistens, dilutes particles. Solvent
mucins
Major glycoprotein component. Mucins + water = mucus. Viscous solution - lubricant function in GI tract
alpha amylase
Catalyses breakdown of polysaccharide (starch, glycogen) into disaccharide (maltose) + glucose
electrolytes
Tonicity/pH
lysozyme
Bacteriocidal - cleaves polysaccharide component of bacterial cell wall
what does mucous cells secrete
mucin
what do serous cells secrete
ezymes such as lipase
what controls salivary secretion
Controlled by parasympathetic and sympathetic NS
Both stimulatory
what controls the parasympathetic aspect of salivary secretion
Cranial nerves VII (facial) & IX (glossopharyngeal)
what does parasympathetic stimulate
profuse watery salivary secretion
what does sympathetic stimulate
small volume of saliva, viscous salivary secretion
High mucus content (α1 adrenoceptors) norepinephrine and sympathetic (more mucins to be converted to mucus)
High amylase content (β2 adrenoceptors) mainly in serous alveoli or alveoli cells
what are the four layers that make up the osophagus
Mucosa, submucosa, muscularis externa and adventitia
what type of epithelium is osophagus, mouth and anal mucosa lined by
stratified squamous epithelium (non-keratinised)
Muscularis externa
upper 1/3 (superior)
skeletal muscle
Muscularis externa
lower 2/3 (inferior)
smooth muscle
whar regulates movement of material into and out of the oesophagus
Upper and lower oesophageal sphincters
what is the oral phase of swallowing
Bolus pushed to back of mouth by tongue
what is the pharyngeal phase of swallowing
Presence of bolus ⇒ sequence of reflex contractions of pharyngeal muscles
what are the sequence of reflex contractions of pharyngeal muscles coordinated by
swallowing centre (medulla)
what does the soft palate close off
it is reflected backward and upward - closes off nasopharynx
what occurs as bolus approached oesophagus after swallowing
Upper oesophageal sphincter (UOS) relaxes and epiglottis covers opening to larynx (prevents food entering trachea)
what happens once food has entered the oesophagus
UOS contracts (prevents food reflux)
oesophageal phase
Propulsion of bolus to stomach aided by peristaltic wave - sweeps along entire oesophagus
how long does it take to propel bolus from oesophagus to stomach
10 seconds
what occurs as bolus nears stomach
Lower oesophageal sphincter (LOS) relaxes ⇒ bolus enters stomach
when is receptive relaxation of stomach
Initiated following relaxation of LOS and entry of bolus into stomach
vagal reflexes
relaxation of thin, elastic smooth muscle of gastric fundus and body
what can the stomach volume range between
50ml ⇒ 1500ml (no change in pressure)
what are the five different functions of the stomach
Temporary store of ingested material
Dissolve food particles and initiate digestive process
Control delivery of contents to small intestine
Sterilise ingested material
Produce intrinsic factor (Vitamin B12 absorption)
what are the anatomical structures a bolus meets in order
Oesophagus ⇒ gastroesophageal (cardiac) opening (lower oesophageal (cardiac) sphincter) ⇒ cardiac region ⇒ fundus ⇒ body (greater and lesser curvature) ⇒pyloric region ⇒ pyloric opening (pyloric sphincter)
Serosa
connective tissue outer layer
Muscularis externae
three layers: longitudinal (outer), circular (middle), oblique (inner)
Submucosa and mucosa folded
(= rugae) when empty ⇒ stretch as stomach fills
Mucus neck secrete
mucus
Parietal secretes
HCL and IF
Chief cells
secretes Pepsinogen