Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

immunology 1139 > Unit 5 Part 2 > Flashcards

Unit 5 Part 2 Flashcards

1
Q

the lymphoid system includes (5)

A

lymphocytes, lymphatic vessels, lymph nodules, primary and secondary lymphoid organs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

name 3 lymphocytes

A

T cells, B cells and NK cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

eg of secondary lymphoid organ

A

spleen and lymph nodes, MALT, GALT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

eg of primary lymphoid organs

A

bone marrow and thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

lymph nodules can be found

A

in Peyer’s patch in small intestine and tonsils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what is hemopoietic stem cells

A

stem cells in adult bone marrow that give rise to immune system cells (also platelets and erythrocytes)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

leukocytes are derived from

A

lymphoid and myeloid lineages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

name 2 types of myeloid cells

A

monocytes/macrophages and granulocytes (BEN)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

fn of hemopoietic GF

A

promote development of stem cells into a specific type of cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

eg of hemopoietic GF

A

granulocyte macrophage colony stimulating factor G-CSF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

describe fn of primary lymphoid organ

A

site for lymphopoiesis, differentiation of lymphoid stem cells into mature and fnal lymphocytes–> bone marrow, thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

describe site of secondary lymphoid organ

A

site where immune response is generated and disseminated. APC, B and T lymphocytes interact w/each other

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what is splenomegaly

A

enlargement of spleen happens during the course of certain infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

differentiation into mature T cells occur under influence of

A

thymic peptide hormones like thymulin, thymosin, and thymopoeitin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

thymic education is a process by which we

A

select useful thymocytes for maturation (+ive selection) and eliminates autoreactive or harmful thymocytes (-ive selection)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what are thymocytes

A

developing T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what does it mean by +ive selection

A

can recognize non-self antigen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

fn of thymic nurse cells

A

specialized cells playing imp role in thymic education of developing T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

CD denotes

A

Clusters of Differentiation or Cluster designation molecules

20
Q

Thymocytes and mature T cells display

A

cell surface markers and CD3 complex

21
Q

purpose of monoclonal antibodues

A

identify cell surface molecules on cells since each cluster is specific for particular molecule

22
Q

Double negative (DN) is

A

CD4- and CD8- early immature thymocytes

23
Q

double postive (DP) is

A

CD4+ or CD8+ developing immature thymocytes

24
Q

single positive (SP) is

A

CD4+ CD8- or CD4- CD8+ mature T cells –>move from thymus to 2nd lymphoid organ

25
Q

CD molecules are involved in

A

intracellular interaxn (CAM such integrins) and/or cell activation, differentiation or proliferation (receptors for cytokines)

26
Q

list an application of cell surface markers

A

identify B and T lymphocytes in patients with lymphoproliferative disorders

27
Q

what is leukemia

A

maturation arrest of stem cells or precursor lymphoid cells

28
Q

name cell surface markers on T cells

A

CD2 and CD3

29
Q

what is CD2 responsible for

A

phenomenon of rosetting with sheep RBC

30
Q

where is CD2 found on

A

all thymocytes and mature T cells

31
Q

where is CD3 found on

A

DP and SP T cells

32
Q

what does CD3 form

A

a stable association w/T cell receptor or TCR to from fnal TCR complex

33
Q

list the 4 mature T cells

A

helper T cells, Tc, regulatory, memory T cells

34
Q

names feature of Th cells

A

CD4 +ive. have diff profiles of cytokine production and immunological fns. recognize antigen in context of class II MHC as presented by APCs

35
Q

features of Th1 (4)

A

produces IL-2, gamma interferon IFNg. activation of cytotoxic T cells, macrophage, inflammatory and delayed hypersenstivity rxns. proinflammatory and cell mediated immunity

36
Q

features of Th2 (4)

A

produces IL-4,6 and 10, activation of B cells and regulation of strong antibody (IgG1 and IgE). promotoes humoral immune response

37
Q

relation of TH1 and TH2

A

cytokines by both inhibit the axns of each other

38
Q

describe Th cells in normal pregnancy

A

Th1 decreases, Th2 increase. reduce CMI and inflammation (enhance fetus survival). increase production of antibodies for placental transfer

39
Q

describe Th cells in recurrent spontaneous abortion

A

increased Th1 and decrease Th2

40
Q

features of cytotoxic T lymphocytes (killer T cells. Tc)

A

CD8 +ive. kills abnormal cells; cancer, virally infected. principle cells responsible for cell mediated immune response. recognize antigens in context of class I MHC present by abnormal cells

41
Q

Features of regulatory T cells

A

CD4 and CD25 +ive. regulation of inflammation and immune response.. supress pathological immune responses

42
Q

what are memory T cells

A

T cells that become stimulated by antigen. long term immunity

43
Q

fn of CD19

A

signal transduction. found in most stage of B cell developement

44
Q

where do B cells mature

A

bone marrow and independent of antigens

45
Q

the mature B cells cell surface markers (2)

A

IgM and IgD. act as receptors for specific antigens

46
Q

mature B cells in response to antigens differentiate to

A

short lived plasma cells that secrete antibodies and long lived memory B cells

immunology 1139 (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions