2nd line of defense: fever Flashcards
what is pyrogenic mean
fever inducing
what is the WBC tht secretes a range of cytokines
activated macrophage
what is the local effect of IL-1
activates vascular endothelium and lymphocytes. local tissue destruction. increase access of effector cells
what is the systemic effect of IL-1
fever and production of IL-6
what is the local effect of TNF alpha
activates vascular endothelium, increases vascular permeability leading to increased entry of IgG, complement, increase drainage to lymph nodes
what is the systemic effect of TNF alpha
fever, mobilization of metabolites and shock
what is the local effect of IL-6
lymphocyte activation, increase antibody production
what is the systemic effect of IL-6
fever, induce acute-phase protein production
what is the local effect of IL-8
chemotactic factor recruits neutrophils, basophil and T cells to site of infection
what is the local effect of IL-12
activate NK cells, induces the differentiation of CD4 into TH1 cells
define endogenous pyrogens
cytokines produced in response to tissue damage (eg from infection) to raise body temp
eg of endogenous pyrogens
IL-1, IL-6 and tumor necrosis factor alpha
define cytokines
chemical messengers produced by cells (eg macrophages) that regulate the inflammatory and immune responses
how do cytokines work
regulates (immune and accessory) cells such as differentiation, multiplication and activation
define cytokine storm
hypercytokinemia (too much cytokines produced)
