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Cytogen > Unit 5 - Chromosomal Basis of Inheritance - Episode 1 > Flashcards

Unit 5 - Chromosomal Basis of Inheritance - Episode 1 Flashcards

1
Q

under transmission genetics

A

Mendelian Inheritance

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2
Q

What is the principle behind the transmission genetics?

A
  1. Blending hypothesis
  2. Particulate Hypothesis of Inheritance
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3
Q

traits of mother + traits of the father = yun yung traits mo

A

Blending hypothesis

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4
Q

It fails to explain the reappearance of traits after they’ve skipped generation

A

Blending hypothesis

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5
Q

this is the gene idea

main focus of mendelian inheritance

A

Particulate Hypothesis of Inheritance

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6
Q

the discrete heritable units

namamana or napapasa sa atin

A

Gene

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7
Q

may bagay or substance sa katawan natin na napapasa from generation to generation.

Hindi nawawala yung trait sa next generation since naipapasa or napapamana natin ito.

A

Particulate Hypothesis of Inheritance

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8
Q

It is a fertilization in which two gametes come from the same individual.

Nagfefertilize mag-isa.

A

Self-fertilization

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9
Q

other term for self-fertilization

A

selfing / pagsosolo

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10
Q

naturally self–fertilized; they have egg producing organ and sperm producing organ.

A

Pea Plants

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11
Q

In the case of pea plants:

_______ is the pollen producing organ. This pollen will now release sperm.

A

Stamen

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12
Q

In the case of pea plants:

________: the egg – bearing organ

A

Carpel

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13
Q

Facilitates fertilization between separate individuals

Magkahiwalay yung egg and sperm, nasa magkaibang specie.

A

Cross-fertilization

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14
Q

Other name for cross-fertilization

A

Cross-breeding

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15
Q

We remove the stamen so that walang magfefertilize doon sa egg and then kukuha ng pollen from other plants tapos yun ang ilalagay sa carpel.

A

cross-fertilization

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16
Q

Offspring of your parents that differ in only one genetic characteristics

A

Monohybrid

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17
Q

Offspring of your parents that differ in only two genetic characteristics

An organism heterozygous with two loci

A

Dihybrid

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18
Q

Genetic factors/fraction that helps determine your characteristics

A

Gene

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19
Q

Alternate forms of a gene

A

Allele

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20
Q

Set of alleles that an individual possesses

Genetic makeup

A

Genotype

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21
Q

Observable characteristics of an organism

A

Phenotype

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22
Q

Two types of Genotype

A
  1. Homozygous
  2. Heterozygous
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23
Q

alleles are the same (PP or pp)

A

Homozygous

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24
Q

alleles are different (Pp)

A

Heterozygous

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25
Q

_________ alleles determines the organism’s appearance

A

Dominant

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26
Q

______ allele has no noticeable effect on the appearance of an individual.

A

Recessive

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27
Q

If dominant allele is present, it will always be followed

A

(Law of Dominance)

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28
Q

A characteristic of an individual that is transmitted from generation to generation.

A

Trait/Character

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29
Q

A mating between two individuals, leading to fusion of gametes

A

Cross

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30
Q

The progeny of mating of individuals of the P generation

A

F1 generation (the first filial generation)

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31
Q

The progeny resulting from F1 generation individuals

A

F2 generation (the second filial generation)

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32
Q

The specific place on a chromosome where a gene is located

A

Locus (gene locus; plural loci)

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33
Q

Parental generation in breeding experiments

A

P generation

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34
Q

When a trait being studied remains unchanged from parent to offspring for many generations. Typically this means that there is homozygosity for the allele responsible for the trait

A

True-breeding

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35
Q

The cell produced by the fusion of male and female gametes

A

Zygote

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36
Q

Father of Genetics

A

Gregor Mendel

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37
Q

Gregor Mendel is an Australian Monk in _______

A

Brno (Czech Republic)

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38
Q

Mendel conducted breeding experiments form ____ to ____

A

1856 to 1863

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39
Q

Mendel presented his results publicly at meeting of the ____________ in 1865

A

Brno National Science Society

40
Q

Mendel’s paper from these lectures was published in ____

A

1866

41
Q

Mendel’s experiment was not recognized due to lack of evidences not until individual experiments were conducted by

A

Hugo De Vries,
Karl Franz Joseph Erich Correns,
Seysenegg (Erich von) Tschermak

42
Q

previous generation is same sayo; pure blood

A

True-breeding

43
Q

single characteristics passed on

A

Monohybrid cross

44
Q

This mating, or crossing, of two true-breeding varieties is called

A

hybridization

45
Q

The true – breeding parents are referred to as the

A

P generation or Parental generation

46
Q

MONOHYBRID CROSS STEPS

A
  1. To cross different varieties of peas, remove the anthers (stamen) to prevent self-fertilization.
  2. Dust the stigma with pollen from a different plant
  3. The pollen (sperm) fertilizes the ova within the flower, which develop into seeds.
  4. The seed grows into plants.
47
Q

discovered the Punnett square

A

Reginald C. Punnett

48
Q

is a handy diagrammatic device for predicting the allele composition of offspring from a cross between individuals at known genetic makeup.

A

Punnett Square

49
Q

BREAK TIME: MUSIC PLAYED DURING LECTURE:

A
  • I Wish You Would by Taylor Swift
  • Robbers by The 1975
  • Anti-Romantic by Tomorrow x Together
50
Q

(Degree of Dominance) masking of recessive traits by dominant traits. Common.

A

Complete Dominance

51
Q

(Degree of Dominance) neither allele is completely dominant. A phenomenon where either of the traits cannot be distinguished from each other (blending of traits – white + red = pink). Not common.

A

Incomplete Dominance

52
Q

two alleles affect the phenotype in separate, distinguishable ways. Both dominant and recessive alleles affect the phenotype. Example: ABO Blood Group

A

Codominance

53
Q

first described the theory of dominance among blood groups.

A

Bernstein (1924)

54
Q

An individual inherits one ABO gene from each parent and these two genes determine which ABO antigens are present in the RBC membrane.

A

Transmission Genetics in Blood Group

55
Q

location of ABO genes. (palatandaan na ang ABO is codominant in expression.)

A

Chromosome 9

56
Q

amorph; group O phenotype is an autosomal recessive trait. Two O must be present to become a blood type O.

A

O gene

57
Q

Mendel’s First Law

A

Principle of Segregation

58
Q

During gametes formation, two alleles segregate randomly with each gamete having equal probability of receiving either allele.

A

Law of Segragation

59
Q

Law of segregation and ______________________ works hand in hand

It explains law of segregation

A

chromosome theory of heredity

60
Q

states that genes are located on chromosomes

A

The chromosome theory of inheritance

61
Q

Probability scale ranges from 0 to 1.

An event that is certain to occur has a probability of 1, while an event that is certain not to occur has a probability of 0

The probabilities of all possible outcomes for an event must add up to 1

A

Probability Laws

62
Q

Each probability laws phenomenon is called

A

independent events

63
Q

Used if the events are not mutually exclusive.

Probability of an event occurring in some specific combination is the product of their probabilities.

Both of the event will happen.

A

Multiplication Rule

64
Q

They key indicator for applying the multiplication rule is the word

A

“and”

65
Q

Probability that any one of two or more mutually exclusive events will occur is calculated by adding their individual probabilities.

Only one of the events will happen.

A

Addition Rule

66
Q

The key indicator for applying the addition rule are the words

A

“either” and “or”

67
Q

Appear in both sexes with equal frequency, and both sexes are capable of transmitting these traits to their offspring

A

Autosomal Dominant

68
Q

Every person must have inherited the allele from at least one parent.

DO NOT SKIP GENERATION

A

Autosomal Dominant

69
Q

Inherited disease in which blood cholesterol is greatly elevated due to the defect in cholesterol transport.

A

Familial hypercholesterolemia

70
Q

an essential component of cell membranes and is used in the synthesis of bile salts and several hormones.

A

Cholesterol

71
Q

Since cholesterol is a lipid (a nonpolar, uncharged comp.), it is not readily soluble in the blood (polar, charged solution). Cholesterol must therefore be transported throughout the body in small soluble particles called

A

lipoproteins.

72
Q

consists of a core of lipid surrounded by a shell of charged phospholipids and proteins that dissolves easily in blood

A

Lipoproteins

73
Q

One of the principle lipoproteins in the transport of cholesterol is

A

low-density lipoprotein

74
Q

When an LDL molecule reaches a cell, it attaches to an__________, which then moves the LDL through the cell membrane into the cytoplasm, where it is broken down and its cholesterol is released for use by the cell.

A

LDL receptor

75
Q

Familial hypercholesterolemia is due to a defect in the gene (located on _____________) that normally codes for the LDL receptor.

A

human chromosome 19

76
Q

_________________ang familial hypercholesterolemia kaya walang kakapitan so sa blood lang yung cholesterol.

Lipids kakapit sa LDL receptor para maipasok ang cholesterol sa cell.

A

LDL receptor deficiency

77
Q

Normally appear with equal frequency in both sexes

Appear only when a person inherits two alleles for the trait, one from each parent.

A

Autosomal Recessive

78
Q

TRAIT APPEARS TO SKIP GENERATIONS

A recessive allele may be passed for a number of generations without the trait appearing in a pedigree.

A

Autosomal Recessive

79
Q

Mating between closely related people is called

A

consanguinity

80
Q

The disease results from the accumulation of a lipid called GM2 ganglioside because they lack hexosaminidase A

A

Tay – Sachs Disease

81
Q

GM2 ganglioside is usually broken down by an enzyme called

A

hexosaminidase A

82
Q

Excessive GM2 ganglioside accumulates in the brain, causing

A

swelling and ultimately neurological symptoms.

83
Q

Accumulate chylomicrons

  • Familial chylomicronemia syndrome (FCS)
A

Lipoprotein Lipase Deficiency (LPL)

84
Q

Absence of HDL – transport cholesterol from tissues to liver

Mutation of ABCA1 gene in chromosome

A

Tangiers Disease

85
Q

ABCA1 gene

A

ATP Binding Cassette A1 gene

86
Q

Appear more frequently in males.

Since males need inherit only single copy of allele to display the trait

A

X-Linked Recessive

87
Q

Male also inherit his X chromosome from his mother. Affected males are usually born to unaffected mothers who carry an allele for the trait.

they are not passed from father to son,
because a son inherits his father’s Y
chromosome, not his X.

A

X-linked Recessive

88
Q

Rare X-linked recessive traits appear more often in males than in females and are not passed from father to son. Affected sons are usually born to unaffected mothers; thus X-linked recessive traits ____________________

A

tend to skip generations

89
Q

Results from the absence of a protein necessary for blood to clot.

The complex process of blood clotting consists of a cascade of reactions that includes more than 13 different factors.

A

Hemophilia

90
Q

results from abnormal or missing factor VIII, one of the proteins in the clotting cascade. The gene for factor VIII is located on the tip of the long arm of the X chromosome

A

Hemophilia A

91
Q

Hemophilia A is an ______________________ disorder

A

X-linked recessive

92
Q

People with ________________bleed excessively; even small cuts and bruises can be life threatening. Spontaneous bleeding occurs in joints such as elbows, knees, and ankles, which produces pain, swelling, and erosion of the bone.

A

Hemophilia A

93
Q

Appear more in female

Inherit X chromosomes from both mother and father; so females can receive an X-linked trait from their parents.

traits do not skip generations

A

X-Linked Dominant

94
Q

People with this trait have features that superficially resemble those produced by rickets: bone deformities, stiff spines and joints, bowed legs, and mild growth deficiencies

This disorder is resistant to treatment with vitamin D

A

Hypophosphatemia (Vitamin D resistant rickets)

95
Q

results from the defective transport of phosphate, especially in cells of the kidneys.

A

Hypophosphatemia (Vitamin D resistant rickets)

96
Q

People with this disorder excrete large amounts of phosphate in their urine, resulting in low levels of phosphate in the blood and reduced deposition of minerals in the bone.

Male with this disease are more severely
affected than females.

A

Hypophosphatemia (Vitamin D resistant rickets)

97
Q

Only males are affected. Traits are passed from father to son.

Does not skip generations

A

Y-Linked Trait

Cytogen (12 decks)

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