Sample Questions

Question 1

A tall male with gyneconastia and small testes should have a cytogenetic study to rule out which of the following?
a. Klinefleter Syndrome
b. Fragile X Syndrome
c. Edwards syndrome
d. Turner syndrome
e. NOTA

Answer 1

A. Klinefelter Syndrome

Question 2

If an organism’s diploid chromosome number is 18, how many different possible combinations of homologous chromosomes lining up during meiosis exist for the eggs or sperm produced by that organism?

Answer 2

512 possible combinations of homologous chromosomes

Question 3

Which of the folllowing statements is accurate in regards to prenatal diagnosis?
a. It is standard of care to offer pregnant women of any age chorionic villus sampling
b. First trimester maternal serum AFP screening is mkre accurate for detecting fetal trisomy 21 than second trimester anniocentesis witb fetal karyotypibg
c. Low AGP, high HCG, and low uE3 on a second trimester triple screen indicates an increased risk of Down Syndrome
d. Chorionic Villus Sampling js less risky and more accurate for fetal chromosome abnormalities than amniocentesis
e. NOTA

Answer 3

C.

Question 4

Initiation of protein synthesis begins with
a. binding of 60s ribosomal unit
b binding of 40s ribosomal unit
c. charging of tRNA with specific amino acid
d attachment of aminoacyl tRNA on mRNA
e. NOTA

Answer 4

B

Question 5

A male affected with an X-linked dominant trait will have what proportion of offspring affected with the trait?

Answer 5

All daughters are 100% affected, while the sons are 0% affected (not affected)

Question 6

Boss Filmah was diagnosed with achondroplasia shortly after birth. What inheritance pattern should be discussed with the parents?

Answer 6

Autosomal dominant pattern

Question 7

Nikoleigh has been diagnosed with a mitochondrial disease. His wife Farugh does not have the disease and curtently pregnant. What is the risk that Maryows and Farugh’s child will have the disease?

Answer 7

Zero risk

Question 8

Amniocentesis is performed on a patients at 16 weeks gestation because of her age (she is 36). The final report to tha physician says that the fetus has a 45X/46,XX karyotype, with tge 45,X cell line making 90% of the cells examined. The fetus will mist likely have phenotypic features of which of the following syndromes?
a. Patau syndrome
b Fragile X syndrome
c. Turner syndrome
d. Down syndrome
e. Klinefelter syndrome

Answer 8

C. Turner Syndrome

Question 9

Who discovered genetic ttansformation of a bacterium and cakles the agent responsible the “transforming principle”?

Answer 9

Frederick Griffith

Question 10

FISH can distinguish each of the following chromosomal abnormalities except:
a. anueploidy
b. translocation
c. deletion
d. trinucleotide repeats
e. NOTA

Answer 10

D. Trinucleotide repeats

Question 11

What structure holds the sister chromatids to the spindle fibers?

Answer 11

Kinetochore

Question 12

After the DNA is replicated, and it condenses in prophase, two identical rods of DNA are seen. These are:

Answer 12

Chromatids

Question 13

Protein microarray analysis requires the use of which of the following techniques to generatr protein profile data?
a. electrophoresis
b. MS
c. TLC
d. GC
e. NOTA

Answer 13

A. Mass Spectroscopy