Unit 4: immunotherapy Flashcards
prutitis
itchiness
atopic
denoting a form of allergy in which a hypersensitivity reaction such as dermatitis or asthma may occur in a part of the body not in contact with the allergen.
your immune system is more sensitive to common allergic triggers that you breathe in or eat.
what is atopic dermatitis
Skin disorder (CAD)
Hereditary predisposition
Environmental allergy - type 1 HS
Pruritis, 2o skin lesions (face, ear, abdomen, feet, perianal area)
6mos to 3yr presentation
lokivetmab
cytopoint
oclacitinib
apoquel
what do apoquel and cytopoint have in common?
Inhibition of the IL-31 signaling pathway, but in two different ways
cytopoint (lokivetmab)→ blocks IL31 from binding to receptor
apoquel (oclacitinib) → blocks JAK inside cell
how does apoquel work?
inhibition of IL-31 pathway by blocking JAK
apoquel = oclacitinib
how does cytopoint work?
cytopoint → lokivetman
blocks IL-31 from binding to receptor
what is IL31
cytokine
Member of the gp130/IL-6 family.
IL-6 → pro inflammatory cytokines
what makes IL31
lots of things
Th2, basophils and eosinophils → type I HS (also called type 2 immune reaction)
what cells respond to IL31
Requires two receptors – IL-31RA and oncostatin M (OSMR).
Skin, testis, thymus
T cells
Keratinocytes
Dendritic cells
Eosinophils
Basophils
Macrophages
Dorsal root ganglia (!)
what receptors are needed for IL31
IL-31RA and oncostatin M (OSMR)
how does IL31 cause itch
bind to IL31RA and OSMR receptors on Dorsal root ganglion that cause itch
summary of IL31
side effects of both cytopoint and apoquel
cytopoint- lokivetmab- block IL31 from binding
type III HS → immune complex issue??
apoquel oclacitinib- block JAK 1 and JAK½ (could cause more issues with receptors that also use JAK ½)
