Unit 1 Exam: Ch 1-4

Question 1

What is the primary federal granting agency through which the United States conducts and supports biomedical research?

Answer 1

National Institues of Health (NIH)

Question 2

What is an animal use protocol?

Answer 2

A detailed explanation of a research project involving animals

Question 3

What does the Institutional Animal Care and Use Committee (IACUC) do?
A- review animal use protocols
B- conduct inspections of animal facilities and reviews institutional animal use programs at least every 6 months
C- serve as an information and resource liaison on animal welfare and research concerns
D- all of the above

Answer 3

D- all of the above

Question 4

What is the purpose of the IACUC’s protocol review?

Answer 4

A postapproval monitoring program that helps ensure the IACUC-approved procedures are being followed

Question 5

Which statement regarding the postapproval monitoring (PAM) program is true?
A- a PAM program is mandated by law
B- a PAM program is typically under the control of the attending veterinarian
C- a PAM program helps ensure that IACUC approved procedures are being followed
D- the staff of the PAM program decides what punitive actions are required if deficiencies are noted

Answer 5

C- a PAM program helps ensure that IACUC approved procedures are being followed

Question 6

A systematic investigation to establish facts is the definition of what term?

Answer 6

Research

Question 7

What is the correct name for the acronym IACUC?
A- informational Animal Care and Use Committee
B- Institutional Animal Care and Use Council
C- Instiutional Animal Care and Use Committee
D- Institutional Animal Costs and Use Committee

Answer 7

C- Institutional Animal Care and Use Committee

Question 8

What is the name of the paperwork necessary to request research money?

Answer 8

Grant application

Question 9

What documentation is required before an investigator can begin a study using animals?

Answer 9

IACUC approval of the animal use protocol

Question 10

Which feature must be provided for nonhuman primates as required by the Animal Welfare Act (AWA)?

Answer 10

Psychological enrichment

Question 11

What document must an institution have before the Public Health Service (PHS) will award a grant or contract that involves the use of animals?

Answer 11

An approved Animal Welfare Assurance

Question 12

What must an institution housing USDA- covered animals do annually as required by the Animal Welfare Regulations (AWR)?

Answer 12

Submit a report

Question 13

According to the Guide, how often must the IACUC conduct the facility inspections and program review?

Answer 13

At least once per year

Question 14

Which animal is covered under the Animal Welfare Act (AWA)?
A- Guinea pigs
B- Poultry
C- Birds
D- Horses not used for research

Answer 14

A- Guinea pigs

Question 15

Good Laboratory Practices (GLP) regulations are most likely to be maintained for which type of study?

Answer 15

Food, drug, or environmental safety

Question 16

What is an Animal Welfare Assurance?

Answer 16

An agreement from a research institution outlining how it complies with the Public Health Service Policy

Question 17

Which word is used in the Guide to describe aspects of an animal care program that are essential or imperative to the proper humane care and use of laboratory animals?

Answer 17

Must

Question 18

How often does the AAALAC perform site visits of accredited institutions?

Answer 18

Every 3 years

Question 19

What must a facility create and follow as required by GLP Regulations?

Answer 19

Standard Operating Procedures (SOP)

Question 20

Who is responsible for monitoring a study and ensuring compliance with GLPs?

Answer 20

Quality assurance unit (QAU)

Question 21

Which animals below are covered under the Public Health Service (PHS) Policy's?
A- all vertebrate animals
B- all invertebrate animals
C- all vertebrates except mice
D- all vertebrates and invertebrates

Answer 21

A- All vertebrate animals

Question 22

What is a requirement to maintain AAALAC accreditation?
A- an inspection report from the USDA
B- An annual report by the institution that describes changes to the animal care and use program
C- a $500 certification fee
D- proof of animal welfare training being offered every 6 months

Answer 22

B- an annual report by the institution that describes changes to the animal care and use program

Question 23

What is the purpose of having standard operating procedures?

Answer 23

To ensure uniformity in animal care

Question 24

What is the correct name for the acronym AAALAC?

Answer 24

Association for assessment and accreditation of laboratory animal care

Question 25

Which USDA pain category would correspond with experiments, teaching, research, experiments, or tests causing pain or distress to the animals, for which appropriate anesthetic, analgesic, or tranquilizing drugs were used?

Answer 25

Category D

Question 26

What resource provides guidelines for programs that use agricultural animals for agricultural research or teaching?

Answer 26

Guide for the care and use of agricultural animals in research and training

Question 27

Which organization publishes the guidelines on euthanasia?

Answer 27

American veterinary medical association (AVMA)

Question 28

Which of the 3R principles is addressed if nonanimal alternatives are used instead of animals?

Answer 28

Replacement

Question 29

Which of the following is an example of the 3Rs principle of replacement? A- adding environmental enrichment to a cage B- providing anesthesia after surgery C- using computer models to provide data D- using rats instead of mice

Answer 29

C- using computer models to provide data

Question 30

What is the general term for the policy at an institution that protects individuals from reprisal if the report a problem?

Answer 30

Whistleblower policy

Question 31

What term refers to the concept that the way people behave is based on commonly held core values?

Answer 31

Ethics

Question 32

According to the Guide, what is the term defined as the actions taken to assure that laboratory Nimals are treated according to high ethical and scientific standards?

Answer 32

Humane care

Question 33

When fewer animals are used Ina study, which of the 3Rs principles is being applied?

Answer 33

Reduction

Question 34

What term refers to knowing and following the rules?

Answer 34

Compliance

Question 35

In the decision-making process, which step would come before gathering and accessing all the facts involved?

Answer 35

Identify the issue of concern

Question 36

What is the aim of ethical decisions?

Answer 36

For a balance of cost and benefits for human and animals

Question 37

When organizing your to-do list, how would you prioritize tasks?

Answer 37

In order of importance and deadline demands

Question 38

What is included in the health record for a nonhuman primate?

Answer 38

Physical exams

Question 39

How long are all assurance records related to NIH-funded grants to be maintained?

Answer 39

At least 3 years free completion of the study

Question 40

Which is an example of a centralized management system? A- the main facility is run by one department and satellite facilities are run by the primary investigation group B- each department maintains its own facility C- expenditures and records involving animals are maintained by a separate department that serves all the institution's animal care needs D- each department is responsible for its own animal care staffing

Answer 40

C- expenditures and records involving animals are maintained by a separate department that serves all the instituion's animal care needs

Question 41

``` What is an example of a direct cost? A- animals B- maintenance C- equipment depreciation D- security ```

Answer 41

A- animals

Question 42

``` Which expense is an example of an indirect cost? A- bedding B- animals C- feed D- telephone system ```

Answer 42

D- telephone system

Question 43

If each department within an institution maintains its own animal facility and operating budget, it is considered what type of management system?

Answer 43

Decentralized

Question 44

What is a cost center?

Answer 44

An activity that has expenses but does not directly produce revenue

Question 45

What should you do after you delegate a task?

Answer 45

Follow up to be sure it has been completed

Question 46

``` Which of the following is important whe working with co-workers? A- listening B- clear communication C- conflict resolution D- all of the above ```

Answer 46

D- all of the above

Question 47

Per diem costs are the expenses required to maintain one animal or one cage of animals for how long?

Answer 47

1 day

Question 48

If it costs $54,750 per year to maintain 100 rats, what would the per diem cost?

Answer 48

54750/365/100 = $1.50

Question 49

``` Which time kept onsite requires a current DEA license? A- cleaners B- toxic substances C- anesthetics D- controlled substances ```

Answer 49

D- controlled substances