Chapter 11: Research Methodologies Flashcards
True or False
Some experimental animals have been genetically manipulated to induce specific immune system deficiencies
True
True or False
Nude mice are more susceptible to infections because they are hairless
False
More susceptible because they lack a thymus
True or False
Housing animals that are gentically immunocompromised requires no social protection if the animals are obtained from a supplier that provides adequate testing to ensure the animals are germ-fee at the time of delivery
False
They require social housing and husbandry practices
True or False
Irradiation of research animals is done only to eliminate certain types of cancer
False
Irradiation provides a method of inducing immunosuppression
True or False
A preimmunization blood sample should be collected to identify whether polyclonal antibodies are present before an antigen is injected
True
True or False
For adjuvants, small multiple-site injections are more favorable for producing an adequate antibody response and may be better tolerate than a single large injection
True
True or False
Some strains of inbred rodents have a high incidence of spontaneously developing naturally occurring cancers
True
_______ is the science of poisons and the harmful or noxious effects of these substances have on living organisms
Toxicology
How long should a subacute study last?
1 month
How long should a subchrinic study last?
3 months
How long should a chronic study last?
6 months to 1 year
A substance that damages a developing fetus is called a(n) _______
Teratogen
What segment in reproductive and developmental testing is a study examining the reproductive toxicity in male and female animals?
Segment I
What segment of reproductive and developmental testing is a study examining fetal toxicity?
Segment II
What segment of reproductive and developmental testing is a study examining toxicity in newborn pups?
Segment III
A substance that produces a fever in an animal is called a(n) ___________.
Pyrogen
A(n) _________ induces the production of antibodies.
Antigen
What is a vaccine?
Protects against an infectious disease and is a killed or attenuated form of the disease organism
Multiple antibodies formed to a particular antigen are referred to as ________ antibodies.
Polyclonal
Freund’s complete, Freund’s incomplete, Tiger-Max, and Alhydrogel are examples of _________.
Adjuvants
Antibodies which recognize the same specific portion of an antigen are called ________ antibodies.
Monoclonal
A combination of a cancer cell and an antibody-producing cell is a called a(n) _________.
Hybridoma
The spread of cancer to other sites of the body is referred to as ________.
Metastasis
What are the two classifications of animal cancer models?
1- induced disease
2- spontaneous disease
What is a metabolism cage?
A cage that allows for the measurement of food and water intake and faces and urine output
A(n) _______ apparatus is used to determine the proper placement of needles or cannula to inject o remove substances from the brain.
Stereotaxic
Name the four types of bioimaging
1- ultrasound
2- magnetic resonance imaging (MRI)
3- positron emission tomography (PET)
4- computed tomography (CT)
