Tumor Markers (Part 3)

Question 1

What is useful in the detection of pancreatic and colorectal cancer

Answer 1

Blood Group Antigen: CA 19-9

Question 2

used as a marker for multiple myeloma for over 100 years

Answer 2

Protein Marker: Immunoglobulins

Question 3

Histological marker for melanoma and melanoma metastases

Answer 3

Protein Marker: S-100

Question 4

Used to diagnose differentiated thyroid cancer

Answer 4

Protein Marker: Thyroglobulin and antibodies

Question 5

Used as indicators for therapy in breast cancer

Answer 5

Estrogen and Progesterone Receptors

Question 6

Neuroblastoma and AML and 95% of pancreatic cancers

Answer 6

Genetic oncogenes: ras

Question 7

If activated, there is an association with B- and T-cell lymphoma

Answer 7

Genetic oncogenes: c-myc

Question 8

Amplification is found in breast tumors and used for prognosis

Answer 8

Genetic oncogenes: Her-2/neu

Question 9

Expressed in lymphomas, myeloma, and chronic leukemias

Answer 9

Genetic oncogenes: bcl-2

Question 10

Useful in the diagnosis and in the directing of treatment in CML

Answer 10

Genetic oncogenes: BCR-ABL

Question 11

Loss of banding on this gene leads to a rare pediactric tumor called retinoblastoma

Answer 11

Tumor-Suppressor Genes: Retinoblastoma gene

Question 12

Deletions in this gene may bead to colon carcinoma

Answer 12

Tumor-Suppressor Genes: p53 gene

Question 13

Loss leads to colorectal cancer with or without many polyps

Answer 13

Tumor-Suppressor Genes: APC

Question 14

Reasonably certain prediction that the woman will develop breat (85% of patients) or ovarian cancer (45%) by the age of 85

Answer 14

Tumor-Suppressor Genes: BRCA1 and BRCA2